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Cyp2a4 Gene Detail
Summary
  • Symbol
    Cyp2a4
  • Name
    cytochrome P450, family 2, subfamily a, polypeptide 4
  • Synonyms
    Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88596
    NCBI Gene: 13086
Location & Maps
more
  • Sequence Map
    Chr7:26307169-26315088 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7920 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 14.39 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CYP2A13, cytochrome P450 family 2 subfamily A member 13
  • Vertebrate Orthologs
    14
  • Human Ortholog
    CYP2A13, cytochrome P450 family 2 subfamily A member 13
    Orthology source: HomoloGene
  • Synonyms
    CPAD, CYP2A, CYPIIA13
  • Links
    NCBI Gene ID: 1553
    neXtProt AC: NX_Q16696

  • Chr Location
    19q13.2; chr19:41088451-41096195 (+)  GRCh38.p2

  • Human Ortholog
    CYP2A6, cytochrome P450 family 2 subfamily A member 6
    Orthology source: HomoloGene
  • Synonyms
    CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
  • Links
    NCBI Gene ID: 1548
    neXtProt AC: NX_P11509

  • Chr Location
    19q13.2; chr19:40843538-40850447 (-)  GRCh38.p2

  • Human Ortholog
    CYP2A7, cytochrome P450 family 2 subfamily A member 7
    Orthology source: HomoloGene
  • Synonyms
    CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
  • Links
    NCBI Gene ID: 1549
    neXtProt AC: NX_P20853

  • Chr Location
    19q13.2; chr19:40875439-40882752 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with human CYP2A6 associations

Human Disease Mouse Models
       Coumarin Resistance   OMIM: 122700
Cytochrome P450, Subfamily IIA, Polypeptide 6; CYP2A6   OMIM: 122720
Lung Cancer   OMIM: 211980
Tobacco Addiction, Susceptibility to   OMIM: 188890
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Cyp2a4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058416 VEGA Gene Model | MGI Sequence Detail 7920 C57BL/6J ±  kb
transcript OTTMUST00000143461 VEGA | MGI Sequence Detail 1738 Not Applicable  
polypeptide OTTMUSP00000074786 VEGA | MGI Sequence Detail 494 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    86 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 4
    cDNA 10
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-18618, MGD-MRK-2298, MGD-MRK-2313, MGI:101806, MGI:2142076
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:30977 Burkhart BA, et al., Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation. J Biol Chem. 1985 Dec 5;260(28):15357-61
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory