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Cyp2a4
Gene Detail
Symbol

Name
ID
Cyp2a4
cytochrome P450, family 2, subfamily a, polypeptide 4
MGI:88596
Synonyms
Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
Feature Type
protein coding gene
Genetic Map
Chromosome 7
14.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:26307192-26315088 bp, + strand
From NCBI annotation of GRCm38

  7897 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:85917  Vertebrate Homology Class
3 human; 2 mouse; 1 rat; 1 rhesus macaque; 7 western clawed frog

Protein SuperFamily: cytochrome P450 CYP2D6
Gene Tree: Cyp2a4

Human
homologs
Human Homolog CYP2A6, cytochrome P450, family 2, subfamily A, polypeptide 6
NCBI Gene ID 1548
neXtProt AC  NX_P11509
Human Synonyms  CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
Human Chr (Location)  19q13.2; chr19:40843538-40850447 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human CYP2A6
Human Homolog CYP2A7, cytochrome P450, family 2, subfamily A, polypeptide 7
NCBI Gene ID 1549
neXtProt AC  NX_P20853
Human Synonyms  CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
Human Chr (Location)  19q13.2; chr19:40875439-40882752 (-)  GRCh38
Human Homolog CYP2A13, cytochrome P450, family 2, subfamily A, polypeptide 13
NCBI Gene ID 1553
neXtProt AC  NX_Q16696
Human Synonyms  CPAD, CYP2A, CYPIIA13
Human Chr (Location)  19q13.2; chr19:41088451-41096195 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Genomic Mutations involving Cyp2a4 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cyp2a4 interacts with 36 markers (Mir92-2, Mir142, Mir148a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process coumarin metabolic process, epoxygenase P450 pathway, ...
Component cytoplasm, cytoplasmic microtubule, ...
Function arachidonic acid epoxygenase activity, coumarin 7-hydroxylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (113)    Tissues (107)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 101
RT-PCR 12
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(4) cDNA(10) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000074254 (Evidence)
Entrez Gene13086 (Evidence)
Consensus CDS ProjectCCDS21002.1
International Mouse Knockout Project StatusCyp2a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13086 NCBI Gene Model | MGI Sequence Detail 7897 C57BL/6J ±  kb
transcript NM_009997 RefSeq | MGI Sequence Detail 1715 FVB/N 
polypeptide NP_034127 RefSeq | MGI Sequence Detail 494 FVB/N 

For the selected sequences
All sequences(21) RefSeq(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(172 from dbSNP Build 137)    SNPs within 2kb including multiple locations(330)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000006220 cytochrome P450 2A4
References
(Earliest) J:30977 Burkhart BA, et al., Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation. J Biol Chem. 1985 Dec 5;260(28):15357-61
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGD-MRK-18618, MGD-MRK-2298, MGD-MRK-2313, MGI:101806, MGI:2142076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory