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Cyp2a4 Gene Detail
Summary
  • Symbol
    Cyp2a4
  • Name
    cytochrome P450, family 2, subfamily a, polypeptide 4
  • Synonyms
    Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88596
    NCBI Gene: 13086
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:26307192-26315088 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 14.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    11
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88596
protein coding gene Chr7:26307169-26315088 (.)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031871
protein coding gene Chr7:24810860-24965337 (+)
AKR/J MGP_AKRJ_G0031801
protein coding gene Chr7:25429390-25452377 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0031591
protein coding gene Chr7:25258109-25288415 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032340
protein coding gene Chr7:26283310-26309038 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029395
protein coding gene Chr7:26094404-26102261 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031556
protein coding gene Chr7:26658970-26704017 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0031663
protein coding gene Chr7:24171107-24201418 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031706
protein coding gene Chr7:26952813-26963925 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030491
protein coding gene Chr7:16137463-16145273 (+)
WSB/EiJ MGP_WSBEiJ_G0031041
protein coding gene Chr7:25291597-25319804 (+)



Homology
more
  • Human Ortholog
    CYP2A13, cytochrome P450 family 2 subfamily A member 13
  • Vertebrate Orthologs
    14
  • Human Ortholog
    CYP2A13, cytochrome P450 family 2 subfamily A member 13
    Orthology source: HomoloGene
  • Synonyms
    CPAD, CYP2A, CYPIIA13
  • Links
    NCBI Gene ID: 1553
    neXtProt AC: NX_Q16696
    UniProt: Q16696

  • Chr Location
    19q13.2; chr19:41088451-41096195 (+)  GRCh38.p7

  • Human Ortholog
    CYP2A6, cytochrome P450 family 2 subfamily A member 6
    Orthology source: HomoloGene
  • Synonyms
    CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
  • Links
    NCBI Gene ID: 1548
    neXtProt AC: NX_P11509
    UniProt: P11509

  • Chr Location
    19q13.2; chr19:40843538-40850447 (-)  GRCh38.p7

  • Human Ortholog
    CYP2A7, cytochrome P450 family 2 subfamily A member 7
    Orthology source: HomoloGene
  • Synonyms
    CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
  • Links
    NCBI Gene ID: 1549
    neXtProt AC: NX_P20853
    UniProt: P20853

  • Chr Location
    19q13.2; chr19:40875439-40885952 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human CYP2A6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13086 NCBI Gene Model | MGI Sequence Detail 7897 C57BL/6J ±  kb
transcript NM_009997 RefSeq | MGI Sequence Detail 1715 FVB/N  
polypeptide P15392 UniProt | EBI | MGI Sequence Detail 494 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 4
    cDNA 11
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-18618, MGD-MRK-2298, MGD-MRK-2313, MGI:101806, MGI:2142076
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:30977 Burkhart BA, et al., Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation. J Biol Chem. 1985 Dec 5;260(28):15357-61
  • Latest
    J:256166 Creasy KT, et al., Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Gene Expr. 2016;17(1):7-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory