Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYP11B1,CYP11B2
  • Mouse genes Cyp11b2
  • Rat genes Cyp11b2,Cyp11b3
  • Zfish genes cyp11c1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyp11b2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047783	corticosterone 18-monooxygenase activity	Cyp11b2	IDA		Rat	PMID:11832364|RGD:727991
Molecular Function	GO:0047783	corticosterone 18-monooxygenase activity	Cyp11b2	IDA		Rat	PMID:2350348|RGD:727645
Molecular Function	GO:0047783	corticosterone 18-monooxygenase activity	Cyp11b3	IDA		Rat	PMID:7829497|RGD:1299585
Molecular Function	GO:0020037	heme binding	CYP11B2	IDA		Human	PMID:23322723
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B1	IMP		Human	PMID:2022736
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B1	IDA		Human	PMID:2256920
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B1	IDA		Human	PMID:8506298
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B2	IDA		Human	PMID:1741400
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B2	IDA		Human	PMID:2256920
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	CYP11B2	IDA		Human	PMID:23322723
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	Cyp11b2	IDA		Mouse	PMID:1686470
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	Cyp11b2	IDA		Mouse	PMID:8645611
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	Cyp11b2	IDA		Rat	PMID:8333830|RGD:727656
Molecular Function	GO:0004507	steroid 11-beta-monooxygenase activity	Cyp11b3	IDA		Rat	PMID:7829497|RGD:1299585
Cellular Component	GO:0030425	dendrite	Cyp11b2	IDA		Rat	PMID:12459034|RGD:1600827
Cellular Component	GO:0005739	mitochondrion	CYP11B1	IDA		Human	PMID:2256920
Cellular Component	GO:0005739	mitochondrion	CYP11B2	IDA		Human	PMID:1741400
Cellular Component	GO:0005739	mitochondrion	CYP11B2	IDA		Human	PMID:2256920
Biological Process	GO:0030325	adrenal gland development	Cyp11b3	IEP		Rat	PMID:7829497|RGD:1299585
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B1	IMP		Human	PMID:19342457
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B1	IDA		Human	PMID:2256920
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B2	IDA		Human	PMID:1741400
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B2	IMP		Human	PMID:19342457
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B2	IDA		Human	PMID:2256920
Biological Process	GO:0032342	aldosterone biosynthetic process	CYP11B2	IDA		Human	PMID:23322723
Biological Process	GO:0032342	aldosterone biosynthetic process	Cyp11b2	IDA		Mouse	PMID:8645611
Biological Process	GO:0032342	aldosterone biosynthetic process	Cyp11b2	IDA		Mouse	PMID:1686470
Biological Process	GO:0032342	aldosterone biosynthetic process	Cyp11b2	IDA		Rat	PMID:11832364|RGD:727991
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	CYP11B1	IDA		Human	PMID:2256920
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	CYP11B2	IDA		Human	PMID:2256920
Biological Process	GO:0006700	C21-steroid hormone biosynthetic process	Cyp11b2	IDA		Rat	PMID:11832364|RGD:727991
Biological Process	GO:0032870	cellular response to hormone stimulus	CYP11B1	IEP		Human	PMID:19342457
Biological Process	GO:0032870	cellular response to hormone stimulus	CYP11B2	IEP		Human	PMID:19342457
Biological Process	GO:0071260	cellular response to mechanical stimulus	Cyp11b2	IEP		Rat	PMID:19478813|RGD:4891163
Biological Process	GO:0031670	cellular response to nutrient	Cyp11b2	IEP		Rat	PMID:16876110|RGD:4891413
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Cyp11b2	IEP		Rat	PMID:20685870|RGD:4891144
Biological Process	GO:0035865	cellular response to potassium ion	CYP11B1	IEP		Human	PMID:19342457
Biological Process	GO:0035865	cellular response to potassium ion	CYP11B2	IEP		Human	PMID:19342457
Biological Process	GO:0051365	cellular response to potassium ion starvation	Cyp11b2	IEP		Rat	PMID:20685870|RGD:4891144
Biological Process	GO:0034651	cortisol biosynthetic process	CYP11B1	IMP		Human	PMID:19342457
Biological Process	GO:0034651	cortisol biosynthetic process	CYP11B1	IMP		Human	PMID:2022736
Biological Process	GO:0034651	cortisol biosynthetic process	CYP11B1	IDA		Human	PMID:8506298
Biological Process	GO:0034651	cortisol biosynthetic process	CYP11B2	IMP		Human	PMID:19342457
Biological Process	GO:0034650	cortisol metabolic process	cyp11c1	IMP	ZFIN:ZDB-MRPHLNO-140414-1	Zfish	PMID:24167225
Biological Process	GO:0042756	drinking behavior	Cyp11b2	IMP	MGI:MGI:3582593	Mouse	PMID:16118390
Biological Process	GO:0006704	glucocorticoid biosynthetic process	Cyp11b2	IDA		Rat	PMID:11832364|RGD:727991
Biological Process	GO:0008584	male gonad development	cyp11c1	IMP	ZFIN:ZDB-GENO-210923-11	Zfish	PMID:32222764
Biological Process	GO:0007617	mating behavior	cyp11c1	IMP	ZFIN:ZDB-GENO-210923-11	Zfish	PMID:32222764
Biological Process	GO:0050801	monoatomic ion homeostasis	Cyp11b2	IMP	MGI:MGI:3582593	Mouse	PMID:16118390
Biological Process	GO:0045777	positive regulation of blood pressure	Cyp11b2	IMP		Rat	PMID:18495825|RGD:2307304
Biological Process	GO:0055075	potassium ion homeostasis	CYP11B2	IMP		Human	PMID:9838244
Biological Process	GO:0008217	regulation of blood pressure	CYP11B1	IMP		Human	PMID:2022736
Biological Process	GO:0002017	regulation of blood volume by renal aldosterone	CYP11B2	IMP		Human	PMID:14614232
Biological Process	GO:0002017	regulation of blood volume by renal aldosterone	Cyp11b2	IMP	MGI:MGI:3582593	Mouse	PMID:16118390
Biological Process	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	Cyp11b2	IMP	MGI:MGI:3582593	Mouse	PMID:16118390
Biological Process	GO:0032868	response to insulin	Cyp11b2	IEP		Rat	PMID:16043663|RGD:2307296
Biological Process	GO:0007584	response to nutrient	Cyp11b2	IEP		Rat	PMID:16882930|RGD:1600074
Biological Process	GO:0043434	response to peptide hormone	Cyp11b2	IEP		Rat	PMID:18252953|RGD:2307305
Biological Process	GO:0043434	response to peptide hormone	Cyp11b3	IEP		Rat	PMID:7829497|RGD:1299585
Biological Process	GO:0009651	response to salt stress	Cyp11b2	IEP		Rat	PMID:19118098|RGD:2307302
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp11b2	IEP		Rat	PMID:16043663|RGD:2307296
Biological Process	GO:0009410	response to xenobiotic stimulus	Cyp11b2	IEP		Rat	PMID:18154949|RGD:2307306
Biological Process	GO:0055078	sodium ion homeostasis	CYP11B2	IMP		Human	PMID:9838244
Biological Process	GO:0008202	steroid metabolic process	Cyp11b3	IDA		Rat	PMID:7829497|RGD:1299585

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern