Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CXXC5
  • Mouse genes Cxxc5
  • Rat genes Cxxc5,LOC681300
  • Zfish genes cxxc5a,cxxc5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cxxc5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	CXXC5	IDA		Human	PMID:23303788
Molecular Function	GO:0008327	methyl-CpG binding	CXXC5	IDA		Human	PMID:29276034
Molecular Function	GO:0043565	sequence-specific DNA binding	CXXC5	IDA		Human	PMID:23303788
Molecular Function	GO:0008270	zinc ion binding	CXXC5	IDA		Human	PMID:29276034
Cellular Component	GO:0005829	cytosol	CXXC5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CXXC5	IDA		Human	GO_REF:0000052
Biological Process	GO:0001947	heart looping	cxxc5a	IMP	ZFIN:ZDB-MRPHLNO-130729-9	Zfish	PMID:27077543
Biological Process	GO:0001947	heart looping	cxxc5a	IGI	ZFIN:ZDB-GENE-000511-1,ZFIN:ZDB-MRPHLNO-130729-9	Zfish	PMID:27077543
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	CXXC5	IDA		Human	PMID:23303788
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	CXXC5	HMP		Human	PMID:12761501
Biological Process	GO:0048793	pronephros development	cxxc5a	IMP	ZFIN:ZDB-MRPHLNO-100521-14	Zfish	PMID:20220130
Biological Process	GO:0048793	pronephros development	cxxc5a	IMP	ZFIN:ZDB-MRPHLNO-100521-13	Zfish	PMID:20220130
Biological Process	GO:0002040	sprouting angiogenesis	cxxc5a	IMP	ZFIN:ZDB-MRPHLNO-140304-1	Zfish	PMID:24136587

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern