Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTLA4
  • Mouse genes Ctla4
  • Rat genes Ctla4
  • Zfish genes cd28
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctla4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P42081	Human	PMID:11279501
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P33681	Human	PMID:11279502
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P33681	Human	PMID:20587542
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P33681	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P42081	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P42081	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:A2RU14	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:Q13021	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:Q4LDR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P27986	Human	PMID:7807015
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P27986	Human	PMID:9398332
Molecular Function	GO:0005515	protein binding	CTLA4	IPI	UniProtKB:P27986	Human	PMID:9813138
Molecular Function	GO:0005515	protein binding	Ctla4	IPI	RGD:737082	Rat	PMID:15849541|RGD:2302005
Cellular Component	GO:0045334	clathrin-coated endocytic vesicle	CTLA4	IDA		Human	PMID:15814706
Cellular Component	GO:0009897	external side of plasma membrane	CTLA4	IDA		Human	PMID:18641304
Cellular Component	GO:0009897	external side of plasma membrane	Ctla4	IDA		Mouse	PMID:16227984
Cellular Component	GO:0005794	Golgi apparatus	CTLA4	IDA		Human	PMID:15814706
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CTLA4	IDA		Human	PMID:15814706
Cellular Component	GO:0005886	plasma membrane	CTLA4	IMP		Human	PMID:28484017
Cellular Component	GO:0098636	protein complex involved in cell adhesion	CTLA4	IDA		Human	PMID:7544393
Biological Process	GO:0050853	B cell receptor signaling pathway	CTLA4	IMP		Human	PMID:17875758
Biological Process	GO:0006974	DNA damage response	CTLA4	IMP		Human	PMID:17875758
Biological Process	GO:0030889	negative regulation of B cell proliferation	CTLA4	IMP		Human	PMID:17875758
Biological Process	GO:0050777	negative regulation of immune response	Ctla4	IMP		Rat	PMID:15849541|RGD:2302005
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	CTLA4	IDA		Human	PMID:18641304
Biological Process	GO:0042130	negative regulation of T cell proliferation	Ctla4	IMP		Rat	PMID:15849541|RGD:2302005
Biological Process	GO:0043065	positive regulation of apoptotic process	CTLA4	IMP		Human	PMID:17875758

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern