Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes COL4A1
  • Mouse genes Col4a1
  • Rat genes Col4a1
  • Zfish genes col4a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Col4a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005201	extracellular matrix structural constituent	COL4A1	IMP		Human	PMID:20818663
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	COL4A1	IMP		Human	PMID:16107487
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	COL4A1	HDA		Human	PMID:28344315
Molecular Function	GO:0048407	platelet-derived growth factor binding	COL4A1	IDA		Human	PMID:8900172
Molecular Function	GO:0005515	protein binding	COL4A1	IPI	UniProtKB:P08572	Human	PMID:12011424
Cellular Component	GO:0005604	basement membrane	Col4a1	IDA		Mouse	MGI:MGI:3776221|PMID:16041630
Cellular Component	GO:0005604	basement membrane	Col4a1	IDA		Mouse	PMID:18757743
Cellular Component	GO:0005604	basement membrane	Col4a1	IDA		Mouse	PMID:15895400
Cellular Component	GO:0005604	basement membrane	Col4a1	IDA		Mouse	PMID:11511678
Cellular Component	GO:0005604	basement membrane	Col4a1	IDA		Mouse	PMID:11732842
Cellular Component	GO:0005587	collagen type IV trimer	COL4A1	IMP		Human	PMID:16107487
Cellular Component	GO:0005587	collagen type IV trimer	Col4a1	IDA		Mouse	PMID:12101409
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A1	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A1	HDA		Human	PMID:23979707
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A1	HDA		Human	PMID:27068509
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A1	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A1	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A1	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	COL4A1	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col4a1	HDA		Mouse	MGI:MGI:5582867|PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col4a1	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Col4a1	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0005615	extracellular space	Col4a1	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Biological Process	GO:0071711	basement membrane organization	COL4A1	IMP		Human	PMID:18160688
Biological Process	GO:0071711	basement membrane organization	COL4A1	IMP		Human	PMID:19949034
Biological Process	GO:0071711	basement membrane organization	COL4A1	IMP		Human	PMID:23065703
Biological Process	GO:0048514	blood vessel morphogenesis	COL4A1	IMP		Human	PMID:20818663
Biological Process	GO:0007420	brain development	COL4A1	IMP		Human	PMID:16107487
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	COL4A1	IMP		Human	PMID:20818663
Biological Process	GO:0071230	cellular response to amino acid stimulus	Col4a1	IDA		Mouse	PMID:20548288
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Col4a1	IGI	MGI:MGI:2152695	Mouse	PMID:10970885
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Col4a1	IGI	MGI:MGI:88455	Mouse	PMID:10970885
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Col4a1	IGI	MGI:MGI:88456	Mouse	PMID:10970885
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Col4a1	IGI	MGI:MGI:104688	Mouse	PMID:10970885
Biological Process	GO:0030855	epithelial cell differentiation	Col4a1	IEP		Rat	PMID:8635488|RGD:2311343
Biological Process	GO:0007528	neuromuscular junction development	Col4a1	IMP	MGI:MGI:3579521	Mouse	PMID:17418794
Biological Process	GO:0061333	renal tubule morphogenesis	COL4A1	IMP		Human	PMID:18160688
Biological Process	GO:0061304	retinal blood vessel morphogenesis	COL4A1	IMP		Human	PMID:20818663

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern