Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CNTFR
  • Mouse genes Cntfr
  • Rat genes Cntfr
  • Zfish genes cntfr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cntfr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	CNTFR	IDA		Human	PMID:12643274
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	Cntfr	IGI	MGI:MGI:88439	Mouse	PMID:7585948
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	Cntfr	IMP		Rat	PMID:8381290|RGD:1304013
Molecular Function	GO:0019955	cytokine binding	CNTFR	IPI	UniProtKB:Q9UBD9	Human	PMID:15272019
Molecular Function	GO:0019955	cytokine binding	Cntfr	IPI	RGD:2370	Rat	PMID:1648265|RGD:1626161
Molecular Function	GO:0005515	protein binding	CNTFR	IPI	UniProtKB:P26441	Human	PMID:18775332
Molecular Function	GO:0005515	protein binding	CNTFR	IPI	UniProtKB:Q8IVG9	Human	PMID:19386761
Molecular Function	GO:0005515	protein binding	CNTFR	IPI	UniProtKB:P26441	Human	PMID:20584990
Molecular Function	GO:0005515	protein binding	CNTFR	IPI	UniProtKB:Q92673	Human	PMID:26858303
Molecular Function	GO:0005515	protein binding	CNTFR	IPI	UniProtKB:Q9UBD9:PRO_0000015616	Human	PMID:26858303
Molecular Function	GO:0005515	protein binding	Cntfr	IPI	PR:P83714	Mouse	PMID:15051883
Molecular Function	GO:0005102	signaling receptor binding	CNTFR	IPI	UniProtKB:P40189	Human	PMID:12707266
Molecular Function	GO:0005102	signaling receptor binding	CNTFR	IPI	UniProtKB:P42702	Human	PMID:12707266
Cellular Component	GO:0016324	apical plasma membrane	CNTFR	IDA		Human	PMID:21912637
Cellular Component	GO:0070110	ciliary neurotrophic factor receptor complex	CNTFR	IDA		Human	PMID:12643274
Cellular Component	GO:0097059	CNTFR-CLCF1 complex	CNTFR	IDA		Human	PMID:11285233
Biological Process	GO:0003360	brainstem development	Cntfr	IMP	MGI:MGI:2181046	Mouse	PMID:7585948
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	CNTFR	IDA		Human	PMID:12643274
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	Cntfr	IGI	MGI:MGI:88439	Mouse	PMID:7585948
Biological Process	GO:0097049	motor neuron apoptotic process	Cntfr	IMP	MGI:MGI:2181046	Mouse	PMID:11312299
Biological Process	GO:0097049	motor neuron apoptotic process	Cntfr	IMP	MGI:MGI:3528869	Mouse	PMID:18588528
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	Cntfr	IMP	MGI:MGI:3528869	Mouse	PMID:18588528
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	Cntfr	IMP	MGI:MGI:2181046	Mouse	PMID:11312299
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	CNTFR	IMP		Human	PMID:19386761
Biological Process	GO:0048680	positive regulation of axon regeneration	cntfr	IMP	ZFIN:ZDB-MRPHLNO-140620-5	Zfish	PMID:24523552
Biological Process	GO:0008284	positive regulation of cell population proliferation	Cntfr	IGI	MGI:MGI:2684607	Mouse	PMID:15051883
Biological Process	GO:0007548	sex differentiation	Cntfr	IMP	MGI:MGI:2181046	Mouse	PMID:10526311
Biological Process	GO:0060538	skeletal muscle organ development	Cntfr	IMP	MGI:MGI:2181046	Mouse	PMID:10526311
Biological Process	GO:0001967	suckling behavior	Cntfr	IMP	MGI:MGI:2181046	Mouse	PMID:7585948

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern