Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLCN2
  • Mouse genes Clcn2
  • Rat genes Clcn2
  • Zfish genes clcn2a,clcn2b,clcn2c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clcn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005254	chloride channel activity	clcn2a	IDA		Zfish	PMID:25236920
Molecular Function	GO:0005254	chloride channel activity	clcn2b	IDA		Zfish	PMID:25236920
Molecular Function	GO:0005247	voltage-gated chloride channel activity	CLCN2	IDA		Human	PMID:29403011
Molecular Function	GO:0005247	voltage-gated chloride channel activity	Clcn2	IMP	MGI:MGI:2183262	Mouse	PMID:11976342
Molecular Function	GO:0005247	voltage-gated chloride channel activity	Clcn2	IDA		Rat	PMID:1311421|RGD:69809
Cellular Component	GO:0030054	cell junction	clcn2c	IPI	UniProtKB:Q14CZ8	Zfish	PMID:25236920
Cellular Component	GO:0030054	cell junction	clcn2c	IDA		Zfish	PMID:25236920
Cellular Component	GO:0030054	cell junction	clcn2a	IPI	UniProtKB:Q14CZ8	Zfish	PMID:25236920
Cellular Component	GO:0030054	cell junction	clcn2a	IDA		Zfish	PMID:25236920
Cellular Component	GO:0030054	cell junction	clcn2b	IDA		Zfish	PMID:25236920
Cellular Component	GO:0030054	cell junction	clcn2b	IPI	UniProtKB:Q14CZ8	Zfish	PMID:25236920
Cellular Component	GO:0030425	dendrite	Clcn2	IDA		Rat	PMID:12967985|RGD:2303820
Cellular Component	GO:0043204	perikaryon	Clcn2	IDA		Rat	PMID:12967985|RGD:2303820
Cellular Component	GO:0005886	plasma membrane	CLCN2	IDA		Human	PMID:29403011
Biological Process	GO:0090425	acinar cell differentiation	Clcn2	IMP	MGI:MGI:2183262	Mouse	PMID:11976342
Biological Process	GO:0060689	cell differentiation involved in salivary gland development	Clcn2	IMP	MGI:MGI:2183262	Mouse	PMID:11976342
Biological Process	GO:0055064	chloride ion homeostasis	clcn2c	IMP	ZFIN:ZDB-MRPHLNO-160104-1	Zfish	PMID:26327813
Biological Process	GO:0006821	chloride transport	Clcn2	IDA		Rat	PMID:1311421|RGD:69809
Biological Process	GO:0030324	lung development	Clcn2	IMP		Rat	PMID:14711803|RGD:1358647
Biological Process	GO:0032347	regulation of aldosterone biosynthetic process	CLCN2	IMP		Human	PMID:29403011
Biological Process	GO:0060041	retina development in camera-type eye	Clcn2	IMP		Mouse	PMID:21052544

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern