Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRM2
  • Mouse genes Chrm2
  • Rat genes Chrm2
  • Zfish genes chrm2a,chrm2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990763	arrestin family protein binding	CHRM2	IPI	UniProtKB:P17870	Human	PMID:11566136
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	CHRM2	IDA		Human	PMID:24256733
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	Chrm2	IMP	MGI:MGI:2155543	Mouse	PMID:9990086
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	Chrm2	IDA		Rat	PMID:12534975|RGD:724727
Molecular Function	GO:0016907	G protein-coupled acetylcholine receptor activity	chrm2a	IDA		Zfish	PMID:31619590
Cellular Component	GO:0032279	asymmetric synapse	Chrm2	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0043679	axon terminus	Chrm2	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0098981	cholinergic synapse	Chrm2	EXP		Mouse	PMID:11880500
Cellular Component	GO:0098981	cholinergic synapse	Chrm2	IMP		Mouse	PMID:11880500
Cellular Component	GO:0030425	dendrite	Chrm2	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0098978	glutamatergic synapse	Chrm2	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0016020	membrane	CHRM2	IDA		Human	PMID:11566136
Cellular Component	GO:0016020	membrane	Chrm2	IDA		Rat	PMID:15961389|RGD:1598749
Cellular Component	GO:0016020	membrane	Chrm2	IDA		Rat	PMID:8320877|RGD:2303388
Cellular Component	GO:0043025	neuronal cell body	Chrm2	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0005886	plasma membrane	CHRM2	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005886	plasma membrane	CHRM2	IDA		Human	PMID:24256733
Cellular Component	GO:0005886	plasma membrane	Chrm2	IDA		Rat	PMID:12534975|RGD:724727
Cellular Component	GO:0045211	postsynaptic membrane	Chrm2	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0042734	presynaptic membrane	Chrm2	IDA		Rat	PMID:8182478|RGD:2303389
Cellular Component	GO:0032280	symmetric synapse	Chrm2	IDA		Rat	PMID:8182478|RGD:2303389
Biological Process	GO:0003161	cardiac conduction system development	chrm2a	IMP	ZFIN:ZDB-MRPHLNO-200403-1	Zfish	PMID:31619590
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	CHRM2	IDA		Human	PMID:24256733
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	Chrm2	IMP	MGI:MGI:2155543	Mouse	PMID:9990086
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	Chrm2	IDA		Rat	PMID:12534975|RGD:724727
Biological Process	GO:0010459	negative regulation of heart rate	chrm2a	IMP	ZFIN:ZDB-MRPHLNO-100510-9	Zfish	PMID:19515979
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrm2	EXP		Mouse	PMID:11880500
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrm2	IMP		Mouse	PMID:11880500
Biological Process	GO:0006940	regulation of smooth muscle contraction	Chrm2	IDA		Rat	PMID:12185001|RGD:724728
Biological Process	GO:0009615	response to virus	CHRM2	IEP		Human	PMID:16548883

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern