Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CERS2
  • Mouse genes Cers2
  • Rat genes Cers2
  • Zfish genes cers2a,cers2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cers2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016410	N-acyltransferase activity	Cers2	IMP		Mouse	MGI:MGI:4421488|PMID:19801672
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:O15245	Human	PMID:11543633
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:P07306	Human	PMID:11543633
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:P07307	Human	PMID:11543633
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:P27449	Human	PMID:11543633
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:P07900	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:Q9BW60	Human	PMID:20937905
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:Q9GZR5	Human	PMID:20937905
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:Q9H5J4	Human	PMID:20937905
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:Q9HB03	Human	PMID:20937905
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:Q9NXB9	Human	PMID:20937905
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:Q9NYP7	Human	PMID:20937905
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:O15245	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:P07306	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:P07307	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:P27449	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:O95070	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:Q9Y5U9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CERS2	IPI	UniProtKB:Q16236	Human	PMID:32911434
Molecular Function	GO:0005515	protein binding	Cers2	IPI	UniProtKB:Q91WD5	Mouse	MGI:MGI:6479469|PMID:32279995
Molecular Function	GO:0005515	protein binding	Cers2	IPI	UniProtKB:Q8R104	Mouse	MGI:MGI:5755322|PMID:26620563
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	CERS2	IDA		Human	PMID:17977534
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	CERS2	IDA		Human	PMID:18165233
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	CERS2	IDA		Human	PMID:29632068
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	Cers2	IDA		Mouse	PMID:15823095
Molecular Function	GO:0050291	sphingosine N-acyltransferase activity	Cers2	IDA		Mouse	PMID:23275342
Cellular Component	GO:0005783	endoplasmic reticulum	CERS2	IDA		Human	PMID:18165233
Cellular Component	GO:0016020	membrane	CERS2	HDA		Human	PMID:19946888
Biological Process	GO:0106097	cellular response to ceramide	cers2b	IGI	ZFIN:ZDB-GENO-180830-1	Zfish	PMID:28956531
Biological Process	GO:0046513	ceramide biosynthetic process	CERS2	IDA		Human	PMID:17977534
Biological Process	GO:0046513	ceramide biosynthetic process	CERS2	IDA		Human	PMID:18165233
Biological Process	GO:0046513	ceramide biosynthetic process	CERS2	IDA		Human	PMID:29632068
Biological Process	GO:0046513	ceramide biosynthetic process	Cers2	IDA		Mouse	MGI:MGI:5755322|PMID:26620563
Biological Process	GO:0046513	ceramide biosynthetic process	Cers2	IMP		Mouse	MGI:MGI:4421488|PMID:19801672
Biological Process	GO:0046513	ceramide biosynthetic process	Cers2	IDA		Mouse	PMID:15823095
Biological Process	GO:0048681	negative regulation of axon regeneration	Cers2	IMP		Rat	PMID:22393241|RGD:11041067
Biological Process	GO:1900148	negative regulation of Schwann cell migration	Cers2	IMP		Rat	PMID:22393241|RGD:11041067
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	Cers2	IMP		Rat	PMID:22393241|RGD:11041067
Biological Process	GO:1905045	negative regulation of Schwann cell proliferation involved in axon regeneration	Cers2	IMP		Rat	PMID:22393241|RGD:11041067
Biological Process	GO:0019216	regulation of lipid metabolic process	Cers2	IMP		Mouse	MGI:MGI:6479469|PMID:32279995
Biological Process	GO:0030148	sphingolipid biosynthetic process	Cers2	IDA		Mouse	PMID:15823095

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern