Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CERKL
  • Mouse genes Cerkl
  • Rat genes Cerkl
  • Zfish genes cerkl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cerkl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046625	sphingolipid binding	Cerkl	IDA		Mouse	PMID:23501591
Cellular Component	GO:0005737	cytoplasm	Cerkl	IDA		Mouse	PMID:21151604
Cellular Component	GO:0005829	cytosol	CERKL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	cerkl	IDA		Zfish	PMID:23671706
Cellular Component	GO:0005654	nucleoplasm	CERKL	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Cerkl	IDA		Mouse	PMID:23142158
Cellular Component	GO:0005634	nucleus	Cerkl	IDA		Mouse	PMID:21151604
Cellular Component	GO:0005634	nucleus	cerkl	IDA		Zfish	PMID:23671706
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Cerkl	IDA		Mouse	PMID:21151604
Cellular Component	GO:0001917	photoreceptor inner segment	Cerkl	IDA		Mouse	PMID:23142158
Cellular Component	GO:0001750	photoreceptor outer segment	Cerkl	IDA		Mouse	PMID:23142158
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	cerkl	IMP	ZFIN:ZDB-MRPHLNO-140620-9	Zfish	PMID:24735978
Biological Process	GO:0042461	photoreceptor cell development	cerkl	IMP	ZFIN:ZDB-MRPHLNO-130719-2	Zfish	PMID:23671706
Biological Process	GO:2000425	regulation of apoptotic cell clearance	cerkl	IMP	ZFIN:ZDB-GENO-170906-1	Zfish	PMID:28398482
Biological Process	GO:0010842	retina layer formation	cerkl	IMP	ZFIN:ZDB-MRPHLNO-130719-2	Zfish	PMID:23671706
Biological Process	GO:0030148	sphingolipid biosynthetic process	Cerkl	IMP	MGI:MGI:5461515	Mouse	PMID:23501591

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern