Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD46
  • Mouse genes Cd46
  • Rat genes Cd46
  • Zfish genes im:7151449,si:ch73-217n20.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd46

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	CD46	IPI	UniProtKB:P12830	Human	PMID:23086448
Molecular Function	GO:0004175	endopeptidase activity	Cd46	IDA		Rat	PMID:15215199|RGD:2293559
Molecular Function	GO:0005515	protein binding	CD46	IPI	UniProtKB:P01024	Human	PMID:18796626
Molecular Function	GO:0005515	protein binding	CD46	IPI	UniProtKB:P01024	Human	PMID:23086448
Molecular Function	GO:0005515	protein binding	CD46	IPI	UniProtKB:P78504	Human	PMID:23086448
Cellular Component	GO:0001669	acrosomal vesicle	Cd46	IDA		Rat	PMID:15601919|RGD:2293573
Cellular Component	GO:0016323	basolateral plasma membrane	Cd46	IDA		Rat	PMID:16425382|RGD:1600479
Cellular Component	GO:0009986	cell surface	CD46	IDA		Human	PMID:23086448
Cellular Component	GO:0009986	cell surface	Cd46	IDA		Rat	PMID:16425382|RGD:1600479
Cellular Component	GO:0009986	cell surface	Cd46	IDA		Rat	PMID:7690370|RGD:2293575
Cellular Component	GO:0005737	cytoplasm	Cd46	IDA		Rat	PMID:16425382|RGD:1600479
Cellular Component	GO:0070062	extracellular exosome	CD46	HDA		Human	PMID:20458337
Cellular Component	GO:0005925	focal adhesion	CD46	HDA		Human	PMID:21423176
Cellular Component	GO:0005794	Golgi apparatus	Cd46	IDA		Rat	PMID:15601919|RGD:2293573
Cellular Component	GO:0002079	inner acrosomal membrane	Cd46	IDA		Rat	PMID:15215199|RGD:2293559
Cellular Component	GO:0005886	plasma membrane	CD46	IDA		Human	PMID:20534589
Biological Process	GO:0010629	negative regulation of gene expression	CD46	IDA		Human	PMID:23086448
Biological Process	GO:0010628	positive regulation of gene expression	CD46	IMP		Human	PMID:23086448
Biological Process	GO:0032733	positive regulation of interleukin-10 production	CD46	IDA		Human	PMID:12540904
Biological Process	GO:0032733	positive regulation of interleukin-10 production	CD46	IDA		Human	PMID:23086448
Biological Process	GO:0043382	positive regulation of memory T cell differentiation	CD46	IDA		Human	PMID:12540904
Biological Process	GO:0045862	positive regulation of proteolysis	Cd46	IDA		Rat	PMID:15215199|RGD:2293559
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	CD46	IDA		Human	PMID:12540904
Biological Process	GO:0042102	positive regulation of T cell proliferation	CD46	IDA		Human	PMID:12540904
Biological Process	GO:0071636	positive regulation of transforming growth factor beta production	CD46	IDA		Human	PMID:12540904
Biological Process	GO:0008593	regulation of Notch signaling pathway	CD46	IDA		Human	PMID:23086448
Biological Process	GO:0035581	sequestering of extracellular ligand from receptor	CD46	IDA		Human	PMID:23086448
Biological Process	GO:0002456	T cell mediated immunity	CD46	IMP		Human	PMID:23086448

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern