Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BRCC3
  • Mouse genes Brcc3
  • Rat genes Brcc3
  • Zfish genes brcc3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Brcc3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030234	enzyme regulator activity	BRCC3	IDA		Human	PMID:14636569
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	BRCC3	IDA		Human	PMID:19202061
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	BRCC3	IDA		Human	PMID:28943315
Molecular Function	GO:0140492	metal-dependent deubiquitinase activity	BRCC3	IMP		Human	PMID:19261746
Molecular Function	GO:0140492	metal-dependent deubiquitinase activity	Brcc3	IDA		Mouse	MGI:MGI:7387171|PMID:23246432
Molecular Function	GO:0008237	metallopeptidase activity	BRCC3	IMP		Human	PMID:17525341
Molecular Function	GO:0008237	metallopeptidase activity	BRCC3	IMP		Human	PMID:19214193
Molecular Function	GO:0008237	metallopeptidase activity	BRCC3	IMP		Human	PMID:19261746
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	BRCC3	IDA		Human	PMID:19261749
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:Q9NXR7	Human	PMID:14636569
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:Q6UWZ7	Human	PMID:18077395
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:Q96RL1-1	Human	PMID:18077395
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:Q96RL1-1	Human	PMID:19202061
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:Q6UWZ7	Human	PMID:19261748
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:Q9NXR7	Human	PMID:19261748
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:Q6UWZ7	Human	PMID:19261749
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:Q6UWZ7	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	BRCC3	IPI	UniProtKB:X5D778	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Brcc3	IPI	UniProtKB:E9Q9M8|UniProtKB:O09106	Mouse	MGI:MGI:6867105|PMID:34180153
Molecular Function	GO:0005515	protein binding	Brcc3	IPI	PR:Q80WJ1	Mouse	PMID:23451117
Molecular Function	GO:0005515	protein binding	Brcc3	IPI	PR:Q3TCJ1	Mouse	PMID:22974638
Cellular Component	GO:0070531	BRCA1-A complex	BRCC3	IDA		Human	PMID:17525341
Cellular Component	GO:0070531	BRCA1-A complex	BRCC3	IDA		Human	PMID:19202061
Cellular Component	GO:0070531	BRCA1-A complex	BRCC3	IDA		Human	PMID:19261746
Cellular Component	GO:0070531	BRCA1-A complex	BRCC3	IDA		Human	PMID:19261748
Cellular Component	GO:0070531	BRCA1-A complex	BRCC3	IDA		Human	PMID:19261749
Cellular Component	GO:0070552	BRISC complex	BRCC3	IDA		Human	PMID:19214193
Cellular Component	GO:0070552	BRISC complex	BRCC3	IDA		Human	PMID:24075985
Cellular Component	GO:0005737	cytoplasm	BRCC3	IDA		Human	PMID:24075985
Cellular Component	GO:0000152	nuclear ubiquitin ligase complex	BRCC3	IDA		Human	PMID:14636569
Cellular Component	GO:0005654	nucleoplasm	BRCC3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	BRCC3	IDA		Human	PMID:14636569
Cellular Component	GO:0005634	nucleus	BRCC3	IDA		Human	PMID:19202061
Cellular Component	GO:0000151	ubiquitin ligase complex	BRCC3	IDA		Human	PMID:14636569
Biological Process	GO:0001525	angiogenesis	brcc3	IMP	ZFIN:ZDB-MRPHLNO-120215-4	Zfish	PMID:21596366
Biological Process	GO:0071479	cellular response to ionizing radiation	BRCC3	IMP		Human	PMID:14636569
Biological Process	GO:0006302	double-strand break repair	BRCC3	IMP		Human	PMID:17525341
Biological Process	GO:0006302	double-strand break repair	BRCC3	IMP		Human	PMID:19202061
Biological Process	GO:0006302	double-strand break repair	BRCC3	IMP		Human	PMID:19261746
Biological Process	GO:0006302	double-strand break repair	BRCC3	IMP		Human	PMID:19261748
Biological Process	GO:0070537	histone H2A K63-linked deubiquitination	BRCC3	IMP		Human	PMID:19261746
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	BRCC3	IMP		Human	PMID:17525341
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	BRCC3	IMP		Human	PMID:19261746
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	BRCC3	IMP		Human	PMID:19261748
Biological Process	GO:0045739	positive regulation of DNA repair	BRCC3	IMP		Human	PMID:17525341
Biological Process	GO:0045739	positive regulation of DNA repair	BRCC3	IMP		Human	PMID:19261746
Biological Process	GO:0045739	positive regulation of DNA repair	BRCC3	IMP		Human	PMID:19261748
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	BRCC3	IDA		Human	PMID:28943315
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Brcc3	IDA		Mouse	MGI:MGI:7387171|PMID:23246432
Biological Process	GO:0016579	protein deubiquitination	Brcc3	IDA		Mouse	MGI:MGI:6867105|PMID:34180153
Biological Process	GO:0070536	protein K63-linked deubiquitination	BRCC3	IDA		Human	PMID:17525341
Biological Process	GO:0070536	protein K63-linked deubiquitination	BRCC3	IDA		Human	PMID:19214193
Biological Process	GO:0070536	protein K63-linked deubiquitination	BRCC3	IMP		Human	PMID:24075985
Biological Process	GO:0070536	protein K63-linked deubiquitination	Brcc3	IDA		Mouse	MGI:MGI:7387171|PMID:23246432
Biological Process	GO:0010212	response to ionizing radiation	BRCC3	IMP		Human	PMID:17525341
Biological Process	GO:0010212	response to ionizing radiation	BRCC3	IMP		Human	PMID:19261746
Biological Process	GO:0010212	response to ionizing radiation	BRCC3	IMP		Human	PMID:19261748
Biological Process	GO:0010165	response to X-ray	BRCC3	IDA		Human	PMID:14636569

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern