Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BLK
  • Mouse genes Blk
  • Rat genes Blk
  • Zfish genes blk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Blk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	BLK	IMP		Human	PMID:23555801
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	BLK	IDA		Human	PMID:876631
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q8NDB2	Human	PMID:21978998
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:O43281	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P40763	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:O43281	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P40763	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:O43281	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P40763	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P08670	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:A0A0C4DGF1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:B2RXF5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:O14543	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:O14796	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:O43281-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:O95551	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P27986-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P40763	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P46109	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P49023-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P51114-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P51116	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q13239-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q13322-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q13490	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q6NX45	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q92569	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q96BR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q96N16	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q96Q35-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q9BWW4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q9UGK3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q9UJV3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:Q9UKT9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BLK	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Blk	IPI	PR:Q62018	Mouse	PMID:8636124
Molecular Function	GO:0004713	protein tyrosine kinase activity	BLK	IDA		Human	PMID:30356214
Biological Process	GO:0050853	B cell receptor signaling pathway	BLK	IMP	UniProtKB:Q8NDB2	Human	PMID:23555801
Biological Process	GO:0050853	B cell receptor signaling pathway	BLK	IDA		Human	PMID:876631
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	BLK	IDA		Human	PMID:30356214
Biological Process	GO:0032024	positive regulation of insulin secretion	BLK	IMP		Human	PMID:19667185
Biological Process	GO:0032092	positive regulation of protein binding	BLK	IMP		Human	PMID:23555801

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern