Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ARHGEF18
  • Mouse genes Arhgef18
  • Rat genes Arhgef18
  • Zfish genes arhgef18a,arhgef18b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Arhgef18

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ARHGEF18	IDA		Human	PMID:14512443
Molecular Function	GO:0005515	protein binding	ARHGEF18	IPI	UniProtKB:Q0VF96	Human	PMID:25753039
Cellular Component	GO:0045177	apical part of cell	ARHGEF18	IDA		Human	PMID:22006950
Cellular Component	GO:0005737	cytoplasm	arhgef18b	IDA		Zfish	PMID:25139857
Cellular Component	GO:0005829	cytosol	ARHGEF18	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	ARHGEF18	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	ARHGEF18	HDA		Human	PMID:18570454
Cellular Component	GO:0005886	plasma membrane	ARHGEF18	IDA		Human	GO_REF:0000052
Biological Process	GO:0030036	actin cytoskeleton organization	ARHGEF18	IDA		Human	PMID:14512443
Biological Process	GO:0003341	cilium movement	arhgef18b	IMP	ZFIN:ZDB-MRPHLNO-141110-3	Zfish	PMID:25139857
Biological Process	GO:0051497	negative regulation of stress fiber assembly	ARHGEF18	IMP		Human	PMID:25753039
Biological Process	GO:0150105	protein localization to cell-cell junction	ARHGEF18	IMP	UniProtKB:P18206	Human	PMID:25753039
Biological Process	GO:0008360	regulation of cell shape	ARHGEF18	IDA		Human	PMID:14512443
Biological Process	GO:0007264	small GTPase mediated signal transduction	ARHGEF18	IDA		Human	PMID:14512443

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern