Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AP2S1
  • Mouse genes Ap2s1
  • Rat genes Ap2s1
  • Zfish genes ap2s1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ap2s1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	AP2S1	IPI	UniProtKB:Q6PD74	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	AP2S1	IPI	UniProtKB:Q6PD74	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	AP2S1	IPI	UniProtKB:Q6PD74	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	AP2S1	IPI	UniProtKB:Q6PD74	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Ap2s1	IPI	UniProtKB:P18484,UniProtKB:P63010,UniProtKB:P84092	Mouse	MGI:MGI:5882913|PMID:12086608
Cellular Component	GO:0030122	AP-2 adaptor complex	Ap2s1	IDA		Mouse	MGI:MGI:5882913|PMID:12086608
Cellular Component	GO:0030122	AP-2 adaptor complex	Ap2s1	IDA		Rat	PMID:7593184|RGD:2306270
Cellular Component	GO:0030122	AP-2 adaptor complex	Ap2s1	IDA		Rat	PMID:2040623|RGD:727584
Cellular Component	GO:0098894	extrinsic component of presynaptic endocytic zone membrane	Ap2s1	IDA		Rat	PMID:8682861|RGD:155230785
Cellular Component	GO:0098978	glutamatergic synapse	Ap2s1	EXP		Rat	PMID:17289840|RGD:13432317
Cellular Component	GO:0098978	glutamatergic synapse	Ap2s1	IDA		Rat	PMID:17289840|RGD:13432317
Cellular Component	GO:0098978	glutamatergic synapse	Ap2s1	IMP		Rat	PMID:17289840|RGD:13432317
Cellular Component	GO:0045202	synapse	Ap2s1	IDA		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Ap2s1	EXP		Mouse	PMID:25211037
Biological Process	GO:0046959	habituation	ap2s1	IMP	ZFIN:ZDB-GENO-150701-2	Zfish	PMID:25754827
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Ap2s1	EXP		Rat	PMID:17289840|RGD:13432317
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Ap2s1	IDA		Rat	PMID:17289840|RGD:13432317
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Ap2s1	IMP		Rat	PMID:17289840|RGD:13432317
Biological Process	GO:0048488	synaptic vesicle endocytosis	AP2S1	IDA		Human	PMID:11102472
Biological Process	GO:0048488	synaptic vesicle endocytosis	AP2S1	IMP		Human	PMID:11102472

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern