Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALOX12B
  • Mouse genes Alox12b
  • Rat genes Alox12b
  • Zfish genes si:dkey-17e16.9
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alox12b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12B	IMP		Human	PMID:15629692
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	Alox12b	IDA		Mouse	MGI:MGI:3608217|PMID:16129665
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	Alox12b	IMP		Mouse	MGI:MGI:6316908|PMID:11256953
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	Alox12b	IDA		Mouse	PMID:10100631
Molecular Function	GO:0047677	arachidonate 8(R)-lipoxygenase activity	Alox12b	IMP		Mouse	MGI:MGI:6316908|PMID:11256953
Molecular Function	GO:1990136	linoleate 9S-lipoxygenase activity	Alox12b	IDA		Mouse	MGI:MGI:3608217|PMID:16129665
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ALOX12B	IDA		Human	PMID:21558561
Cellular Component	GO:0005829	cytosol	ALOX12B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ALOX12B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ALOX12B	IDA		Human	PMID:9837935
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Alox12b	IDA		Mouse	MGI:MGI:1316602|PMID:9837935
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX12B	IMP		Human	PMID:15629692
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox12b	IDA		Mouse	MGI:MGI:3608217|PMID:16129665
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox12b	IMP		Mouse	MGI:MGI:6316908|PMID:11256953
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox12b	IMP		Mouse	MGI:MGI:1313249|PMID:10100631
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox12b	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:0046513	ceramide biosynthetic process	Alox12b	IMP		Mouse	MGI:MGI:3789553|PMID:17403930
Biological Process	GO:0061436	establishment of skin barrier	Alox12b	IMP		Mouse	MGI:MGI:3789553|PMID:17403930
Biological Process	GO:0061436	establishment of skin barrier	Alox12b	IMP		Mouse	MGI:MGI:5141179|PMID:21558561
Biological Process	GO:0051122	hepoxilin biosynthetic process	Alox12b	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:0043651	linoleic acid metabolic process	Alox12b	IDA		Mouse	MGI:MGI:3608217|PMID:16129665
Biological Process	GO:0019372	lipoxygenase pathway	ALOX12B	IMP		Human	PMID:15629692
Biological Process	GO:0019372	lipoxygenase pathway	ALOX12B	IDA		Human	PMID:21558561
Biological Process	GO:0010628	positive regulation of gene expression	ALOX12B	IMP		Human	PMID:22441738
Biological Process	GO:0043410	positive regulation of MAPK cascade	ALOX12B	IDA		Human	PMID:22441738
Biological Process	GO:0070257	positive regulation of mucus secretion	ALOX12B	IMP		Human	PMID:22441738
Biological Process	GO:0006497	protein lipidation	Alox12b	IMP		Mouse	MGI:MGI:5141179|PMID:21558561
Biological Process	GO:0006665	sphingolipid metabolic process	ALOX12B	IDA		Human	PMID:21558561

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern