Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ALOX12
  • Mouse genes Alox12
  • Rat genes Alox12
  • Zfish genes alox12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Alox12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12	IDA		Human	PMID:17493578
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12	IDA		Human	PMID:18311922
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12	IDA		Human	PMID:1851637
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12	IDA		Human	PMID:2217179
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12	IDA		Human	PMID:22984144
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12	IDA		Human	PMID:2377602
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12	IDA		Human	PMID:24282679
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	ALOX12	IDA		Human	PMID:8319693
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	Alox12	IMP		Mouse	MGI:MGI:6316908|PMID:11256953
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	Alox12	IDA		Mouse	MGI:MGI:66203|PMID:8188678
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	alox12	IDA		Zfish	PMID:21880725
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	alox12	IMP	ZFIN:ZDB-MRPHLNO-120130-4	Zfish	PMID:22143766
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	alox12	IMP	ZFIN:ZDB-MRPHLNO-120130-3	Zfish	PMID:22143766
Molecular Function	GO:0004052	arachidonate 12(S)-lipoxygenase activity	alox12	IDA		Zfish	PMID:22143766
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX12	IDA		Human	PMID:17493578
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ALOX12	IDA		Human	PMID:18311922
Molecular Function	GO:0005509	calcium ion binding	alox12	IDA		Zfish	PMID:28528958
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	ALOX12	IDA		Human	PMID:8319693
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	Alox12	IMP		Mouse	MGI:MGI:6316908|PMID:11256953
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	alox12	IDA		Zfish	PMID:28528958
Molecular Function	GO:0005515	protein binding	ALOX12	IPI	UniProtKB:P02545	Human	PMID:10727209
Molecular Function	GO:0005515	protein binding	ALOX12	IPI	UniProtKB:P13647	Human	PMID:10727209
Cellular Component	GO:0005737	cytoplasm	ALOX12	IDA		Human	PMID:8319693
Cellular Component	GO:0005737	cytoplasm	Alox12	IDA		Mouse	MGI:MGI:71860|PMID:7868854
Cellular Component	GO:0005737	cytoplasm	Alox12	IDA		Rat	PMID:15107407|RGD:1578311
Cellular Component	GO:0005829	cytosol	ALOX12	IDA		Human	PMID:15107407
Cellular Component	GO:0005829	cytosol	ALOX12	IDA		Human	PMID:8912711
Cellular Component	GO:0005829	cytosol	Alox12	IDA		Rat	PMID:15450084|RGD:2313867
Cellular Component	GO:0005829	cytosol	Alox12	IDA		Rat	PMID:7511046|RGD:2313872
Cellular Component	GO:0070062	extracellular exosome	ALOX12	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	ALOX12	IDA		Human	PMID:8912711
Cellular Component	GO:0005634	nucleus	Alox12	IDA		Rat	PMID:15450084|RGD:2313867
Cellular Component	GO:0005634	nucleus	alox12	IDA		Zfish	PMID:22143766
Cellular Component	GO:0042383	sarcolemma	ALOX12	IDA		Human	PMID:15107407
Cellular Component	GO:0042383	sarcolemma	Alox12	IDA		Rat	PMID:15107407|RGD:1578311
Biological Process	GO:0007568	aging	Alox12	IEP		Rat	PMID:16029322|RGD:2302179
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX12	IDA		Human	PMID:1851637
Biological Process	GO:0019369	arachidonic acid metabolic process	ALOX12	IDA		Human	PMID:8319693
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox12	IMP		Mouse	MGI:MGI:1202206|PMID:9501222
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox12	IDA		Mouse	MGI:MGI:66203|PMID:8188678
Biological Process	GO:0019369	arachidonic acid metabolic process	Alox12	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:0071396	cellular response to lipid	Alox12	IEP		Rat	PMID:18680775|RGD:5509785
Biological Process	GO:0061436	establishment of skin barrier	Alox12	IMP		Mouse	MGI:MGI:1339275|PMID:10383730
Biological Process	GO:0019395	fatty acid oxidation	ALOX12	IMP		Human	PMID:15111312
Biological Process	GO:0019395	fatty acid oxidation	ALOX12	IDA		Human	PMID:17493578
Biological Process	GO:0019395	fatty acid oxidation	ALOX12	IDA		Human	PMID:18311922
Biological Process	GO:0019395	fatty acid oxidation	ALOX12	IDA		Human	PMID:22984144
Biological Process	GO:0019395	fatty acid oxidation	ALOX12	IDA		Human	PMID:23504711
Biological Process	GO:0019395	fatty acid oxidation	ALOX12	IDA		Human	PMID:24282679
Biological Process	GO:0019395	fatty acid oxidation	ALOX12	IDA		Human	PMID:25036362
Biological Process	GO:0019395	fatty acid oxidation	Alox12	IDA		Mouse	MGI:MGI:6355538|PMID:25293588
Biological Process	GO:0051122	hepoxilin biosynthetic process	Alox12	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:1901751	leukotriene A4 metabolic process	ALOX12	IDA		Human	PMID:8250832
Biological Process	GO:0043651	linoleic acid metabolic process	ALOX12	IDA		Human	PMID:8319693
Biological Process	GO:0006629	lipid metabolic process	ALOX12	IDA		Human	PMID:17493578
Biological Process	GO:0006629	lipid metabolic process	ALOX12	IDA		Human	PMID:18311922
Biological Process	GO:0006629	lipid metabolic process	ALOX12	IDA		Human	PMID:22984144
Biological Process	GO:2001303	lipoxin A4 biosynthetic process	ALOX12	IDA		Human	PMID:8250832
Biological Process	GO:2001306	lipoxin B4 biosynthetic process	ALOX12	IDA		Human	PMID:8250832
Biological Process	GO:0019372	lipoxygenase pathway	ALOX12	IDA		Human	PMID:8319693
Biological Process	GO:0019372	lipoxygenase pathway	Alox12	IDA		Mouse	MGI:MGI:66203|PMID:8188678
Biological Process	GO:0019372	lipoxygenase pathway	Alox12	IMP		Mouse	MGI:MGI:1202206|PMID:9501222
Biological Process	GO:0019372	lipoxygenase pathway	Alox12	IDA		Rat	PMID:23382512|RGD:8554649
Biological Process	GO:0043066	negative regulation of apoptotic process	Alox12	IMP		Rat	PMID:8643560|RGD:2313871
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ALOX12	IMP		Human	PMID:23578768
Biological Process	GO:0090331	negative regulation of platelet aggregation	Alox12	IMP		Mouse	MGI:MGI:1202206|PMID:9501222
Biological Process	GO:0043065	positive regulation of apoptotic process	Alox12	IMP		Rat	PMID:15105833|RGD:2313858
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	Alox12	IMP		Rat	PMID:10733500|RGD:2313864
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Alox12	IMP		Rat	PMID:15105833|RGD:2313858
Biological Process	GO:1905956	positive regulation of endothelial tube morphogenesis	Alox12	IMP		Rat	PMID:10733500|RGD:2313864
Biological Process	GO:0010628	positive regulation of gene expression	Alox12	IMP		Rat	PMID:15105833|RGD:2313858
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	Alox12	IMP		Rat	PMID:15564577|RGD:2313870
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	Alox12	IMP		Rat	PMID:15450084|RGD:2313867
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Alox12	IMP		Rat	PMID:16199435|RGD:5509792
Biological Process	GO:0033559	unsaturated fatty acid metabolic process	ALOX12	IDA		Human	PMID:23504711
Biological Process	GO:0033559	unsaturated fatty acid metabolic process	ALOX12	IDA		Human	PMID:24282679
Biological Process	GO:0033559	unsaturated fatty acid metabolic process	ALOX12	IDA		Human	PMID:25036362

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern