About   Help   FAQ
Alox12 Gene Detail
Summary
  • Symbol
    Alox12
  • Name
    arachidonate 12-lipoxygenase
  • Synonyms
    9930022G08Rik, Alox12p, P-12LO
  • Feature Type
    protein coding gene
  • IDs
    MGI:87998
    NCBI Gene: 11684
  • Gene Overview
    MyGene.info: ALOX12
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70241457-70255353 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87998
protein coding gene Chr11:70241455-70255381 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018590
protein coding gene Chr11:70763044-70778573 (-)
A/J MGP_AJ_G0018558
protein coding gene Chr11:68073227-68087109 (-)
AKR/J MGP_AKRJ_G0018527
protein coding gene Chr11:70103792-70119002 (-)
BALB/cJ MGP_BALBcJ_G0018530
protein coding gene Chr11:68396079-68409822 (-)
C3H/HeJ MGP_C3HHeJ_G0018343
protein coding gene Chr11:70142160-70155895 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018981
protein coding gene Chr11:72860099-72873865 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016626
protein coding gene Chr11:64991803-65005275 (-)
CAST/EiJ MGP_CASTEiJ_G0017898
protein coding gene Chr11:70387753-70404378 (-)
CBA/J MGP_CBAJ_G0018315
protein coding gene Chr11:76173013-76189709 (-)
DBA/2J MGP_DBA2J_G0018425
protein coding gene Chr11:67649055-67663494 (-)
FVB/NJ MGP_FVBNJ_G0018415
protein coding gene Chr11:67304568-67318660 (-)
LP/J MGP_LPJ_G0018495
protein coding gene Chr11:71331683-71347080 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018438
protein coding gene Chr11:76738620-76755166 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019023
protein coding gene Chr11:70375601-70392063 (-)
PWK/PhJ MGP_PWKPhJ_G0017672
protein coding gene Chr11:68303005-68317350 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017462
protein coding gene Chr11:70173438-70187080 (-)
WSB/EiJ MGP_WSBEiJ_G0017952
protein coding gene Chr11:70039023-70052769 (-)



Homology
more
  • Human Ortholog
    ALOX12, arachidonate 12-lipoxygenase, 12S type
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ALOX12, arachidonate 12-lipoxygenase, 12S type
    Orthology source: HGNC, HomoloGene
  • Synonyms
    12-LOX, 12S-LOX, LOG12
  • Links
    NCBI Gene ID: 239
    neXtProt AC: NX_P18054
    UniProt: P18054

  • Chr Location
    17p13.1; chr17:6993791-7010736 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit increased basal transepidermal water loss and hypersensitivity to adenosine 5'-diphosphate-induced platelet aggregation and mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000320 Ensembl Gene Model | MGI Sequence Detail 13897 C57BL/6J ±  kb
transcript ENSMUST00000000329 Ensembl | MGI Sequence Detail 3001 Not Applicable  
polypeptide ENSMUSP00000000329 Ensembl | MGI Sequence Detail 663 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 2
    cDNA 24
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1285, MGI:2443819
References
more
  • Summaries
    All 90
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 30
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:260300 Lauder SN, et al., Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Sci Signal. 2017 Nov 28;10(507)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory