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Alox12 Gene Detail
Summary
  • Symbol
    Alox12
  • Name
    arachidonate 12-lipoxygenase
  • Synonyms
    9930022G08Rik, Alox12p, P-12LO
  • Feature Type
    protein coding gene
  • IDs
    MGI:87998
    NCBI Gene: 11684
  • Gene Overview
    MyGene.info: ALOX12
Location & Maps
more
  • Sequence Map
    Chr11:70241457-70255353 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13897 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ALOX12, arachidonate 12-lipoxygenase, 12S type
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ALOX12, arachidonate 12-lipoxygenase, 12S type
    Orthology source: HomoloGene
  • Synonyms
    12-LOX, 12S-LOX, LOG12
  • Links
    NCBI Gene ID: 239
    neXtProt AC: NX_P18054

  • Chr Location
    17p13.1; chr17:6994196-7010754 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Alox12
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit increased basal transepidermal water loss and hypersensitivity to adenosine 5'-diphosphate-induced platelet aggregation and mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006035 VEGA Gene Model | MGI Sequence Detail 13897 C57BL/6J ±  kb
transcript OTTMUST00000013572 VEGA | MGI Sequence Detail 3001 Not Applicable  
polypeptide OTTMUSP00000006289 VEGA | MGI Sequence Detail 663 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    155 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 26
    Genomic 2
    cDNA 23
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1285, MGI:2443819
References
more
  • Summaries
    All 60
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 29
  • Earliest
    J:18190 Chen XS, et al., cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem. 1994 May 13;269(19):13979-87
  • Latest
    J:229029 Yamamoto K, et al., The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J Exp Med. 2015 Oct 19;212(11):1901-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory