Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AKR1B10,AKR1B15
  • Mouse genes Akr1b8
  • Rat genes Akr1b10,Akr1b8
  • Zfish genes akr1b1.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Akr1b8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008106	alcohol dehydrogenase (NADP+) activity	AKR1B10	IDA		Human	PMID:19013440
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952
Molecular Function	GO:0045550	geranylgeranyl reductase activity	AKR1B10	IDA		Human	PMID:21187079
Molecular Function	GO:0047718	indanol dehydrogenase activity	AKR1B10	IDA		Human	PMID:20837989
Molecular Function	GO:0070401	NADP+ binding	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952
Molecular Function	GO:0052650	NADP-retinol dehydrogenase activity	AKR1B10	IDA		Human	PMID:12732097
Molecular Function	GO:0052650	NADP-retinol dehydrogenase activity	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952
Molecular Function	GO:0070402	NADPH binding	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952
Molecular Function	GO:0005515	protein binding	AKR1B10	IPI	UniProtKB:Q13085	Human	PMID:18056116
Molecular Function	GO:0005515	protein binding	AKR1B10	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0016918	retinal binding	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952
Molecular Function	GO:0001758	retinal dehydrogenase activity	AKR1B10	IDA		Human	PMID:21851338
Cellular Component	GO:0005829	cytosol	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952
Cellular Component	GO:0005576	extracellular region	AKR1B10	IDA		Human	PMID:21585341
Cellular Component	GO:0005764	lysosome	AKR1B10	IDA		Human	PMID:21585341
Biological Process	GO:0110095	cellular detoxification of aldehyde	AKR1B10	IDA		Human	PMID:19013440
Biological Process	GO:0110095	cellular detoxification of aldehyde	AKR1B10	IDA		Human	PMID:19563777
Biological Process	GO:0044597	daunorubicin metabolic process	AKR1B10	IMP		Human	PMID:20837989
Biological Process	GO:0044598	doxorubicin metabolic process	AKR1B10	IMP		Human	PMID:20837989
Biological Process	GO:0016488	farnesol catabolic process	AKR1B10	IDA		Human	PMID:21187079
Biological Process	GO:0019751	polyol metabolic process	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952
Biological Process	GO:0042574	retinal metabolic process	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952
Biological Process	GO:0001523	retinoid metabolic process	AKR1B10	IDA		Human	PMID:12732097
Biological Process	GO:0042572	retinol metabolic process	Akr1b10	IDA		Rat	PMID:20709016|RGD:6903952

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern