Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AGO4
  • Mouse genes Ago4
  • Rat genes Ago4
  • Zfish genes ago4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ago4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	AGO4	IDA		Human	PMID:19966796
Molecular Function	GO:0035198	miRNA binding	AGO4	IDA		Human	PMID:15260970
Molecular Function	GO:0005515	protein binding	AGO4	IPI	UniProtKB:P26651	Human	PMID:15766526
Molecular Function	GO:0005515	protein binding	AGO4	IPI	UniProtKB:O15397	Human	PMID:19167051
Molecular Function	GO:0005515	protein binding	AGO4	IPI	UniProtKB:Q8NDV7	Human	PMID:19167051
Molecular Function	GO:0005515	protein binding	AGO4	IPI	UniProtKB:Q8NDV7	Human	PMID:19324964
Molecular Function	GO:0005515	protein binding	AGO4	IPI	UniProtKB:Q8NDV7	Human	PMID:19383768
Molecular Function	GO:0003723	RNA binding	Ago4	IDA		Mouse	PMID:19536157
Molecular Function	GO:0003727	single-stranded RNA binding	AGO4	IDA		Human	PMID:19966796
Cellular Component	GO:0005737	cytoplasm	AGO4	IDA		Human	PMID:15260970
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	AGO4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	AGO4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	AGO4	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	Ago4	IDA		Mouse	PMID:22863743
Cellular Component	GO:0000932	P-body	Ago4	IDA		Mouse	PMID:19898466
Cellular Component	GO:0016442	RISC complex	AGO4	IDA		Human	PMID:15260970
Cellular Component	GO:0016442	RISC complex	AGO4	IDA		Human	PMID:19966796
Cellular Component	GO:0016442	RISC complex	Ago4	IDA		Mouse	PMID:19536157
Cellular Component	GO:0070578	RISC-loading complex	AGO4	IDA		Human	PMID:19966796
Biological Process	GO:0008584	male gonad development	Ago4	IMP	MGI:MGI:5438526	Mouse	PMID:22863743
Biological Process	GO:0007140	male meiotic nuclear division	Ago4	IMP	MGI:MGI:5438526	Mouse	PMID:22863743
Biological Process	GO:0010586	miRNA metabolic process	Ago4	IMP	MGI:MGI:5438526	Mouse	PMID:22863743
Biological Process	GO:0035196	miRNA processing	AGO4	IMP		Human	PMID:22795694
Biological Process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	AGO4	IDA		Human	PMID:18771919
Biological Process	GO:0006402	mRNA catabolic process	AGO4	IDA		Human	PMID:18771919
Biological Process	GO:0043066	negative regulation of apoptotic process	Ago4	IMP	MGI:MGI:5438526	Mouse	PMID:22863743
Biological Process	GO:0031054	pre-miRNA processing	AGO4	IDA		Human	PMID:19966796
Biological Process	GO:0022604	regulation of cell morphogenesis	Ago4	IMP	MGI:MGI:5438526	Mouse	PMID:22863743
Biological Process	GO:0070922	RISC complex assembly	AGO4	IDA		Human	PMID:19966796
Biological Process	GO:0010501	RNA secondary structure unwinding	AGO4	IDA		Human	PMID:19966796
Biological Process	GO:0010501	RNA secondary structure unwinding	AGO4	IMP		Human	PMID:22795694
Biological Process	GO:0007130	synaptonemal complex assembly	Ago4	IMP	MGI:MGI:5438526	Mouse	PMID:22863743

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern