Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AFAP1
  • Mouse genes Afap1
  • Rat genes Afap1
  • Zfish genes afap1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Afap1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Afap1	IPI	RGD:1308800	Rat	PMID:12114187|RGD:625602
Molecular Function	GO:0042169	SH2 domain binding	Afap1	IPI	RGD:1308800	Rat	PMID:12114187|RGD:625602
Molecular Function	GO:0017124	SH3 domain binding	Afap1	IPI	RGD:1308800	Rat	PMID:12114187|RGD:625602
Cellular Component	GO:0015629	actin cytoskeleton	AFAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005884	actin filament	Afap1	IDA		Rat	PMID:12114187|RGD:625602
Cellular Component	GO:0005829	cytosol	AFAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	AFAP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	AFAP1	HDA		Human	PMID:21423176
Biological Process	GO:0071260	cellular response to mechanical stimulus	Afap1	IEP		Rat	PMID:12114187|RGD:625602
Biological Process	GO:0009966	regulation of signal transduction	Afap1	IDA		Rat	PMID:12114187|RGD:625602

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern