Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADRB3
  • Mouse genes Adrb3
  • Rat genes Adrb3
  • Zfish genes adrb3a,adrb3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adrb3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031699	beta-3 adrenergic receptor binding	Adrb3	IDA		Mouse	PMID:9305915
Molecular Function	GO:0031699	beta-3 adrenergic receptor binding	Adrb3	IDA		Mouse	PMID:7738011
Molecular Function	GO:0004939	beta-adrenergic receptor activity	ADRB3	IDA		Human	PMID:15123695
Molecular Function	GO:0015052	beta3-adrenergic receptor activity	ADRB3	IMP		Human	PMID:9892244
Molecular Function	GO:0051379	epinephrine binding	Adrb3	IDA		Rat	PMID:1684635|RGD:632162
Molecular Function	GO:0051380	norepinephrine binding	ADRB3	IDA		Human	PMID:15123695
Molecular Function	GO:0051380	norepinephrine binding	Adrb3	IDA		Rat	PMID:1684635|RGD:632162
Molecular Function	GO:0005515	protein binding	ADRB3	IPI	UniProtKB:P07550	Human	PMID:15123695
Molecular Function	GO:0042803	protein homodimerization activity	ADRB3	IDA		Human	PMID:15123695
Cellular Component	GO:0016020	membrane	Adrb3	IDA		Mouse	PMID:7738011
Cellular Component	GO:0005634	nucleus	Adrb3	IDA		Rat	PMID:16631628|RGD:5129153
Cellular Component	GO:0043235	receptor complex	ADRB3	IDA		Human	PMID:15123695
Biological Process	GO:0007190	activation of adenylate cyclase activity	ADRB3	IDA		Human	PMID:15123695
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adrb3	IDA		Mouse	PMID:7738011
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adrb3	IDA		Rat	PMID:1684635|RGD:632162
Biological Process	GO:0007568	aging	Adrb3	IEP		Rat	PMID:9914406|RGD:2313169
Biological Process	GO:0050873	brown fat cell differentiation	Adrb3	IGI	MGI:MGI:87938	Mouse	PMID:12387862
Biological Process	GO:0050873	brown fat cell differentiation	Adrb3	IGI	MGI:MGI:87937	Mouse	PMID:12387862
Biological Process	GO:0002024	diet induced thermogenesis	Adrb3	IGI	MGI:MGI:87937	Mouse	PMID:12161655
Biological Process	GO:0002024	diet induced thermogenesis	Adrb3	IGI	MGI:MGI:87938	Mouse	PMID:12161655
Biological Process	GO:0042755	eating behavior	Adrb3	IDA		Rat	PMID:10555566|RGD:2313168
Biological Process	GO:0031649	heat generation	Adrb3	IGI	MGI:MGI:87938	Mouse	PMID:12161655
Biological Process	GO:0031649	heat generation	Adrb3	IGI	MGI:MGI:87937	Mouse	PMID:12161655
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Adrb3	IGI	MGI:MGI:87937	Mouse	PMID:12387862
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Adrb3	IGI	MGI:MGI:87938	Mouse	PMID:12387862
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb3	IDA		Mouse	PMID:10358009
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Adrb3	IGI	UniProtKB:P18762,UniProtKB:P34971	Mouse	MGI:MGI:2388907|PMID:12387862
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Adrb3	IMP		Mouse	MGI:MGI:77582|PMID:7493988
Biological Process	GO:0043410	positive regulation of MAPK cascade	ADRB3	IDA		Human	PMID:15123695
Biological Process	GO:0046677	response to antibiotic	Adrb3	IEP		Rat	PMID:16846466|RGD:5684391
Biological Process	GO:0009409	response to cold	Adrb3	IGI	MGI:MGI:87937	Mouse	PMID:12161655
Biological Process	GO:0009409	response to cold	Adrb3	IGI	MGI:MGI:87938	Mouse	PMID:12387862
Biological Process	GO:0009409	response to cold	Adrb3	IGI	MGI:MGI:87938	Mouse	PMID:12161655
Biological Process	GO:0009409	response to cold	Adrb3	IGI	MGI:MGI:87937	Mouse	PMID:12387862
Biological Process	GO:0009409	response to cold	Adrb3	IEP		Rat	PMID:9914406|RGD:2313169

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern