Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADCY6
  • Mouse genes Adcy6
  • Rat genes Adcy6
  • Zfish genes adcy6a,adcy6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adcy6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004016	adenylate cyclase activity	ADCY6	IDA		Human	PMID:17916776
Molecular Function	GO:0004016	adenylate cyclase activity	ADCY6	IDA		Human	PMID:18403039
Molecular Function	GO:0004016	adenylate cyclase activity	ADCY6	IDA		Human	PMID:23842570
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy6	IMP		Mouse	MGI:MGI:4457984|PMID:20466003
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy6	IDA		Mouse	PMID:17593019
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy6	IDA		Rat	PMID:11738086|RGD:2312641
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy6	IDA		Rat	PMID:12711600|RGD:2312674
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy6	IDA		Rat	PMID:15385642|RGD:8554216
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy6	IDA		Rat	PMID:15579502|RGD:2313211
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy6	IDA		Rat	PMID:15961389|RGD:1598749
Molecular Function	GO:0004016	adenylate cyclase activity	Adcy6	IDA		Rat	PMID:17010343|RGD:2315004
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy6	IDA		Mouse	PMID:1379717
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	Adcy6	IDA		Rat	PMID:10894801|RGD:2315006
Molecular Function	GO:0005515	protein binding	ADCY6	IPI	UniProtKB:P24588	Human	PMID:17081159
Molecular Function	GO:0005515	protein binding	ADCY6	IPI	UniProtKB:Q02952	Human	PMID:17081159
Molecular Function	GO:0019901	protein kinase binding	Adcy6	IPI	UniProtKB:P11345	Rat	PMID:15385642|RGD:8554216
Molecular Function	GO:0005080	protein kinase C binding	ADCY6	IDA		Human	PMID:17081159
Molecular Function	GO:0097110	scaffold protein binding	Adcy6	IPI	PR:D3YVF0	Mouse	PMID:20164376
Molecular Function	GO:0005102	signaling receptor binding	Adcy6	IPI	RGD:2348	Rat	PMID:12748066|RGD:1600980
Molecular Function	GO:0000149	SNARE binding	Adcy6	IDA		Rat	PMID:21986494|RGD:8553247
Cellular Component	GO:0005768	endosome	Adcy6	IDA		Rat	PMID:17010343|RGD:2315004
Cellular Component	GO:0016020	membrane	Adcy6	IDA		Rat	PMID:15385642|RGD:8554216
Cellular Component	GO:0045121	membrane raft	Adcy6	IDA		Rat	PMID:12573460|RGD:2312526
Cellular Component	GO:0045121	membrane raft	Adcy6	IDA		Rat	PMID:12748066|RGD:1600980
Cellular Component	GO:0031528	microvillus membrane	Adcy6	IDA		Rat	PMID:10866989|RGD:2312678
Cellular Component	GO:0005886	plasma membrane	Adcy6	IDA		Mouse	MGI:MGI:4457984|PMID:20466003
Cellular Component	GO:0005886	plasma membrane	Adcy6	IDA		Rat	PMID:12748066|RGD:1600980
Cellular Component	GO:0005886	plasma membrane	Adcy6	IDA		Rat	PMID:17010343|RGD:2315004
Cellular Component	GO:0005886	plasma membrane	Adcy6	IDA		Rat	PMID:21986494|RGD:8553247
Cellular Component	GO:0042383	sarcolemma	Adcy6	IDA		Rat	PMID:15961389|RGD:1598749
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ADCY6	IDA		Human	PMID:17916776
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adcy6	IMP		Mouse	MGI:MGI:4457984|PMID:20466003
Biological Process	GO:0097746	blood vessel diameter maintenance	ADCY6	IMP		Human	PMID:17916776
Biological Process	GO:0006171	cAMP biosynthetic process	ADCY6	IDA		Human	PMID:17916776
Biological Process	GO:0006171	cAMP biosynthetic process	ADCY6	IDA		Human	PMID:18403039
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy6	IMP		Mouse	MGI:MGI:4457984|PMID:20466003
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy6	IMP		Rat	PMID:10866989|RGD:2312678
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy6	IDA		Rat	PMID:10894801|RGD:2315006
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy6	IDA		Rat	PMID:11738086|RGD:2312641
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy6	IDA		Rat	PMID:12711600|RGD:2312674
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy6	IDA		Rat	PMID:15579502|RGD:2313211
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy6	IDA		Rat	PMID:15961389|RGD:1598749
Biological Process	GO:0006171	cAMP biosynthetic process	Adcy6	IMP		Rat	PMID:18971210|RGD:2312654
Biological Process	GO:0071870	cellular response to catecholamine stimulus	ADCY6	IDA		Human	PMID:18403039
Biological Process	GO:1904322	cellular response to forskolin	ADCY6	IDA		Human	PMID:17916776
Biological Process	GO:1904322	cellular response to forskolin	Adcy6	IMP		Mouse	MGI:MGI:4457984|PMID:20466003
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	ADCY6	IDA		Human	PMID:18403039
Biological Process	GO:1904117	cellular response to vasopressin	Adcy6	IMP		Mouse	MGI:MGI:4457984|PMID:20466003
Biological Process	GO:0007623	circadian rhythm	Adcy6	IEP		Rat	PMID:16166080|RGD:2312676
Biological Process	GO:0007212	dopamine receptor signaling pathway	ADCY6	IDA		Human	PMID:18403039
Biological Process	GO:0072660	maintenance of protein location in plasma membrane	Adcy6	IMP		Rat	PMID:21986494|RGD:8553247
Biological Process	GO:0022011	myelination in peripheral nervous system	adcy6a	IGI	ZFIN:ZDB-MRPHLNO-140502-1,ZFIN:ZDB-MRPHLNO-140502-2	Zfish	PMID:24319099
Biological Process	GO:0022011	myelination in peripheral nervous system	adcy6b	IGI	ZFIN:ZDB-MRPHLNO-140502-1,ZFIN:ZDB-MRPHLNO-140502-2	Zfish	PMID:24319099
Biological Process	GO:0010977	negative regulation of neuron projection development	Adcy6	IMP		Mouse	MGI:MGI:5298138|PMID:21986494
Biological Process	GO:0010977	negative regulation of neuron projection development	Adcy6	IMP		Rat	PMID:21986494|RGD:8553247
Biological Process	GO:0035811	negative regulation of urine volume	Adcy6	IMP		Mouse	MGI:MGI:4457984|PMID:20466003
Biological Process	GO:0003091	renal water homeostasis	Adcy6	IMP		Mouse	MGI:MGI:4457984|PMID:20466003

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern