Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ADAM12
  • Mouse genes Adam12
  • Rat genes Adam12
  • Zfish genes adam12b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adam12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ADAM12	IPI	UniProtKB:P07948	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	ADAM12	IPI	UniProtKB:P08631	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	ADAM12	IPI	UniProtKB:P12931	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	ADAM12	IPI	UniProtKB:Q8N157	Human	PMID:25825872
Molecular Function	GO:0005515	protein binding	Adam12	IPI	UniProtKB:P35609	Mouse	MGI:MGI:3687806|PMID:10788519
Molecular Function	GO:0017124	SH3 domain binding	ADAM12	IPI	UniProtKB:Q5HYK7-1	Human	PMID:15280379
Molecular Function	GO:0017124	SH3 domain binding	ADAM12	IPI	UniProtKB:Q5HYK7-2	Human	PMID:15280379
Molecular Function	GO:0017124	SH3 domain binding	ADAM12	IPI	UniProtKB:Q5HYK7-4	Human	PMID:15280379
Molecular Function	GO:0017124	SH3 domain binding	ADAM12	IPI	UniProtKB:Q5HYK7-5	Human	PMID:15280379
Cellular Component	GO:0005654	nucleoplasm	ADAM12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADAM12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ADAM12	IDA		Human	PMID:15280379
Biological Process	GO:0045766	positive regulation of angiogenesis	ADAM12	IMP		Human	PMID:28637396

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern