Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCA8
  • Mouse genes Abca8b
  • Rat genes Abca8
  • Zfish genes abca5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abca8b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCA8	IMP		Human	PMID:12379217
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCA8	IDA		Human	PMID:12379217
Cellular Component	GO:0016323	basolateral plasma membrane	Abca8b	IDA		Mouse	MGI:MGI:6479495|PMID:29300488
Cellular Component	GO:0005783	endoplasmic reticulum	ABCA8	IDA		Human	PMID:28882873
Cellular Component	GO:0005743	mitochondrial inner membrane	Abca8b	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005886	plasma membrane	ABCA8	IDA		Human	PMID:28882873
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ABCA8	IMP		Human	PMID:23560799
Biological Process	GO:0010874	regulation of cholesterol efflux	ABCA8	IMP		Human	PMID:28882873
Biological Process	GO:0006686	sphingomyelin biosynthetic process	ABCA8	IMP		Human	PMID:23560799
Biological Process	GO:0042908	xenobiotic transport	ABCA8	IMP		Human	PMID:12379217

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern