Automated description from the Alliance of Genome Resources (Release 8.3.0)
Predicted to enable cyclin binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including mitotic G1 DNA damage checkpoint signaling; positive regulation of dendrite morphogenesis; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within DNA damage response, signal transduction by p53 class mediator; negative regulation of signal transduction by p53 class mediator; and p38MAPK cascade. Located in neuronal cell body. Is expressed in several structures, including adrenal gland; brain; early embryo; genitourinary system; and gut gland. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 45. Orthologous to human FBXO31 (F-box protein 31).
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