Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables thioredoxin-disulfide reductase (NADPH) activity. Involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Acts upstream of or within cellular oxidant detoxification and in utero embryonic development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in Robinow syndrome. Orthologous to human NXN (nucleoredoxin).