Symbol
Name
ID

Tyr
tyrosinase
MGI:98880

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Hypopigmentation of hair	Albinism	White hair	Giant melanosomes in melanocytes	Hypopigmentation of the skin	Absent skin pigmentation	Vitiligo	Nevus
Disease(s) Associated with TYR	Hypopigmentation of hair	Albinism	White hair	Giant melanosomes in melanocytes	Hypopigmentation of the skin	Absent skin pigmentation	Vitiligo	Nevus
ocular albinism 1
oculocutaneous albinism type IA
oculocutaneous albinism type IB
vitiligo

Mouse Phenotypes

integument phenotype

abnormal keratinocyte apoptosis

abnormal ear pigmentation

decreased ear pigmentation

abnormal coat appearance

abnormal coat/hair pigmentation

absent hair follicle melanin granules

abnormal hair follicle melanogenesis

absent coat pigmentation

diluted coat color

irregular coat pigmentation

transverse fur striping

variegated coat color

mottled coat

belly spot

shiny fur

abnormal skin pigmentation

absent skin pigmentation

Availability

Mouse Genotype

Tyr^c-1FATw/Tyr^c-1FATw

Tyr^c-2Btlr/Tyr^c-2Btlr

Tyr^c-2J/Tyr^c-2J

Tyr^c-2MLPm/Tyr^c-2MLPm

Tyr^c-3FAFyh/Tyr^c-3FAFyh

Tyr^c-3FDFoHrd/Tyr^c-3FDFoHrd

Tyr^c-3FR60Hb/Tyr^c-3FR60Hb

Tyr^c-4CFO/Tyr^c-4CFO

Tyr^c-4J/Tyr^c-4J

Tyr^c-6THO-IV/Tyr^c-6THO-IV

Tyr^c-7THO-II/Tyr^c-7THO-II

Tyr^c-8FrS/Tyr^c-8FrS

Tyr^c-9J/Tyr^c-9J

Tyr^c-9Pub/Tyr^c-9Pub

Tyr^c-10J/Tyr^c-10J

Tyr^c-11J/Tyr^c-11J

Tyr^c-12HATh/Tyr^c-12HATh

Tyr^c-15DSD/Tyr^c-15DSD

Tyr^c-15R145M/Tyr^c-15R145M

Tyr^c-16DFiOD/Tyr^c-16DFiOD

Tyr^c-17J/Tyr^c-17J

Tyr^c-17UThc/Tyr^c-17UThc

Tyr^c-18J/Tyr^c-18J

Tyr^c-19J/Tyr^c-19J

Tyr^c-20J/Tyr^c-20J

Tyr^c-24R75M/Tyr^c-24R75M

Tyr^c-27FrThc/Tyr^c-27FrThc

Tyr^c-31HATh/Tyr^c-31HATh

Tyr^c-32DSD/Tyr^c-32DSD

Tyr^c-36FrS/Tyr^c-36FrS

Tyr^c-38R145L/Tyr^c-38R145L

Tyr^c-44H/Tyr^c-44H

Tyr^c-45DSD/Tyr^c-45DSD

Tyr^c-45H/Tyr^c-45H

Tyr^c-46H/Tyr^c-46H

Tyr^c-50H/Tyr^c-50H

Tyr^c-51DTD/Tyr^c-51DTD

Tyr^c-51H/Tyr^c-51H

Tyr^c-62DSD/Tyr^c-62DSD

Tyr^c-65G/Tyr^c-65G

Tyr^c-76UT/Tyr^c-76UT

Tyr^c-77HATh/Tyr^c-77HATh

Tyr^c-177G/Tyr^c-177G

Tyr^c-222THO-I/Tyr^c-222THO-I

Tyr^c-a/Tyr^c-a

Tyr^c-Bc2/Tyr^c-Bc2

Tyr^c-Bc3/Tyr^c-Bc3

Tyr^c-Brd/Tyr^c-Brd

Tyr^c-Btlr/Tyr^c-Btlr

Tyr^c-ch37H/Tyr^c-ch37H

Tyr^c-ch38H/Tyr^c-ch38H

Tyr^c-ch49H/Tyr^c-ch49H

Tyr^c-ch54H/Tyr^c-ch54H

Tyr^c-ch62H/Tyr^c-ch62H

Tyr^c-ch83R/Tyr^c-ch83R

Tyr^c-ch/Tyr^c-ch

Tyr^c-em/Tyr^c-em

Tyr^c-h/Tyr^c-h

Tyr^c-i/Tyr^c-i

Tyr^c-m/Tyr^c-m

Tyr^c-p/Tyr^c-p

Tyr^c-Wtsi/Tyr^c-Wtsi

Tyr^cm1OR/Tyr^cm1OR

Tyr^em2Utr/Tyr^em2Utr

Tyr^em3J/Tyr^em3J

Tyr^em3Ove/Tyr^em3Ove

Tyr^em5Ove/Tyr^em5Ove

Tyr^em6Ove/Tyr^em6Ove

Tyr^em11Ove/Tyr^em11Ove

Tyr^m3Btlr/Tyr^m3Btlr

Tyr^m4Btlr/Tyr^m4Btlr

Tyr^m5Btlr/Tyr^m5Btlr

Tyr^skc35/Tyr^skc35

Tyr^tm1Arte/Tyr^tm1Arte

Gt(ROSA)26Sor^{tm7.1(CAG-EGFP/RNAi:Tyr)Maoh}/Gt(ROSA)26Sor⁺

Tyr^c-1DThWb/Tyr^c

Tyr^c-1FAFyh/Tyr^c

Tyr^c-1FATw/Tyr^c

Tyr^c-1FDFoHrc/Tyr^c

Tyr^c-1FR60Hb/Tyr^c

Tyr^c-2MLPm/Tyr^c

Tyr^c-2R145L/Tyr^c

Tyr^c-2YPSj/Tyr^c

Tyr^c-3DENb/Tyr^c

Tyr^c-3FAFyh/Tyr^c

Tyr^c-3FDFoHrd/Tyr^c

Tyr^c-3FR60Hb/Tyr^c

Tyr^c-3R60L/Tyr^c

Tyr^c-3R145L/Tyr^c

Tyr^c-3YPSd/Tyr^c

Tyr^c-4CFO/Tyr^c

Tyr^c-4FR60Hd/Tyr^c

Tyr^c-4PB/Tyr^c

Tyr^c-5FR60Hg/Tyr^c

Tyr^c-6THO-IV/Tyr^c

Tyr^c-7R250H/Tyr^c

Tyr^c-7THO-II/Tyr^c

Tyr^c-8FrS/Tyr^c

Tyr^c-9FR60Hb/Tyr^c

Tyr^c-9Pub/Tyr^c

Tyr^c-10FR60L/Tyr^c

Tyr^c-10R75M/Tyr^c

Tyr^c-11DSD/Tyr^c

Tyr^c-12FR60Hb/Tyr^c

Tyr^c-12HATh/Tyr^c

Tyr^c-14CoS/Tyr^c

Tyr^c-14FR60Hb/Tyr^c

Tyr^c-15DSD/Tyr^c

Tyr^c-15R60L/Tyr^c

Tyr^c-15R145M/Tyr^c

Tyr^c-16DFiOD/Tyr^c

Tyr^c-16HATh/Tyr^c

Tyr^c-17UThc/Tyr^c

Tyr^c-19DTR/Tyr^c

Tyr^c-20FATw/Tyr^c

Tyr^c-23DVT/Tyr^c

Tyr^c-24R75M/Tyr^c

Tyr^c-24R145L/Tyr^c

Tyr^c-27FrThc/Tyr^c

Tyr^c-31HATh/Tyr^c

Tyr^c-32DSD/Tyr^c

Tyr^c-36FrS/Tyr^c

Tyr^c-38R145L/Tyr^c

Tyr^c-39SAS/Tyr^c

Tyr^c-40H/Tyr^c-ch

Tyr^c-42H/Tyr^c-ch

Tyr^c-43H/Tyr^c-ch

Tyr^c-45DSD/Tyr^c

Tyr^c-51DTD/Tyr^c

Tyr^c-62DSD/Tyr^c

Tyr^c-65G/Tyr^c

Tyr^c-65K/Tyr^c

Tyr^c-68G/Tyr^c

Tyr^c-76UT/Tyr^c

Tyr^c-77HATh/Tyr^c

Tyr^c-112K/Tyr^c-ch

Tyr^c-112K/Tyr^c

Tyr^c-146G/Tyr^c

Tyr^c-177G/Tyr^c

Tyr^c-202G/Tyr^c

Tyr^c-222THO-I/Tyr^c

Tyr^c-a/Tyr^c-ch

Tyr^c-a/Tyr^c-e

Tyr^c-a/Tyr^c-h

Tyr^c-AL/Tyr^c

Tyr^c-Bc/Tyr^c

Tyr^c-ch/Tyr^c-ch38H

Tyr^c-h/Tyr^c-25H

Tyr^c-h/Tyr^c

Tyr^c-LA/Tyr^c

Tyr^c-p/Tyr^c

Tyr^c/Tyr^c-13J

Tyr^c/Tyr^c-43H

Tyr^c/Tyr^c-44H

Tyr^c/Tyr^c-a

Tyr^c/Tyr^c-ch49H

Tyr^c/Tyr^c-ch62H

Tyr^c/Tyr^c-ch83R

Tyr^c/Tyr^em3Ove

Tyr^c/Tyr^em5Ove

Tyr^c/Tyr^em8Ove

Tyr^cm1OR/Tyr^c-ch

Tyr^cm1OR/Tyr^c

Tyr^em2Utr/Tyr^em1Utr

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23