Symbol Name ID |
Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator MGI:1314891 |
Darker colors indicate more annotations |
Human Phenotypes | Sclerosis of skull base |
Increased head circumference |
Bowing of the long bones |
Femoral bowing |
Short femur |
Femur fracture |
Osteosclerosis of the ulna |
Bone pain |
Increased susceptibility to fractures |
Pathologic fracture |
Fractures of the long bones |
Multiple rib fractures |
Sandwich appearance of vertebral bodies |
Vertebral compression fracture |
Osteopetrosis |
Osteoporosis |
Thin bony cortex |
Abnormal trabecular bone morphology |
Osteolysis |
Disease(s) Associated with TNFRSF11A | |||||||||||||||||||
autosomal recessive osteopetrosis 7 | |||||||||||||||||||
familial expansile osteolysis | |||||||||||||||||||
osteoporosis | |||||||||||||||||||
Paget's disease of bone 2 |
Mouse Phenotypes | abnormal osteoclast differentiation |
absent incisors |
failure of tooth eruption |
tooth impaction |
domed cranium |
decreased osteoclast cell number |
increased osteoclast cell number |
abnormal osteoclast morphology |
abnormal osteoclast physiology |
increased femoral compact bone area |
abnormal tibia morphology |
abnormal long bone hypertrophic chondrocyte zone |
increased long bone epiphyseal plate size |
abnormal long bone metaphysis morphology |
increased diameter of long bones |
kyphosis |
abnormal bone structure |
increased bone mineral density |
increased trabecular bone volume |
increased bone volume |
decreased compact bone thickness |
abnormal osteoblast morphology |
increased osteoblast cell number |
abnormal trabecular bone morphology |
increased bone trabecula number |
decreased bone trabecular spacing |
increased trabecular bone thickness |
osteopetrosis |
osteosclerosis |
abnormal skeleton physiology |
abnormal bone mineralization |
abnormal bone remodeling |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||
Tnfrsf11adel8/Tnfrsf11adel8 | |||||||||||||||||||||||||||||||||
Tnfrsf11atm1.1Sral/Tnfrsf11atm1.1Sral | |||||||||||||||||||||||||||||||||
Tnfrsf11atm1.2Pngr/Tnfrsf11atm1.2Pngr | |||||||||||||||||||||||||||||||||
Tnfrsf11atm1Imx/Tnfrsf11atm1Imx | |||||||||||||||||||||||||||||||||
Tnfrsf11atm1Kost/Tnfrsf11atm1Kost | |||||||||||||||||||||||||||||||||
Tnfrsf11atm1Wjb/Tnfrsf11atm1Wjb | |||||||||||||||||||||||||||||||||
Tnfrsf11atm1.1Sral/Tnfrsf11a+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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