Symbol
Name
ID

Gpr161
G protein-coupled receptor 161
MGI:2685054

Phenotype annotations related to nervous system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Cerebellar hemorrhage

Cerebellar calcifications

Abnormal cranial nerve morphology

Hydrocephalus

Cerebellar cyst

Spinal cord tumor

Medulloblastoma

Cerebellar medulloblastoma

Neuroblastoma

Ataxia

Cerebellar ataxia associated with quadrupedal gait

Dysmetria

Progressive cerebellar ataxia

Intention tremor

Increased intracranial pressure

Irritability

Lethargy

Cognitive impairment

Abnormal brain FDG positron emission tomography

Headache

Global developmental delay

Disease(s) Associated with GPR161

medulloblastoma

Mouse Phenotypes

increased neuronal precursor proliferation

abnormal neural tube morphology

enlarged floor plate

spina bifida

abnormal midbrain development

increased midbrain size

enlarged fourth ventricle

enlarged cerebral aqueduct

abnormal midbrain morphology

enlarged tectum

exencephaly

abnormal spinal cord morphology

encephalomeningocele

Availability

Mouse Genotype

Gpr161^tm1Lex/Gpr161^tm1Lex

Gpr161^vl/Gpr161^vl

Gpr161^tm1.2Smuk/Gpr161^tm1.2Smuk
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Gpr161^tm1.2Smuk/Gpr161^tm1.2Smuk
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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