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Symbol
Name
ID 		Wwox
WW domain-containing oxidoreductase
MGI:1931237
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Secondary microcephaly
Progressive microcephaly
Spasticity
Lower limb spasticity
Cerebral calcification
Delayed CNS myelination
Simplified gyral pattern
Thin corpus callosum
Hypoplasia of the corpus callosum
Cerebral atrophy
Cerebellar vermis atrophy
Cerebellar atrophy
Ataxia
Gait ataxia
Limb ataxia
Babinski sign
EEG abnormality
Reduced eye contact
Dysarthria
Intellectual disability
Hyperreflexia
Hyporeflexia
Hypokinesia
Epileptic encephalopathy
Global developmental delay
Seizure
Bilateral tonic-clonic seizure
Bilateral tonic-clonic seizure with focal onset
Generalized non-motor (absence) seizure
Focal clonic seizure
Focal tonic seizure
Generalized clonic seizure
Epileptic spasm
Status epilepticus
Disease(s) Associated with WWOX
autosomal recessive spinocerebellar ataxia 12
developmental and epileptic encephalopathy 28

Mouse Phenotypes
convulsive seizures
tonic-clonic seizures
increased pituitary gland weight
abnormal pituitary gland physiology
microgliosis
increased brain weight
Purkinje cell degeneration
thin cerebellar granule layer
thin cerebellar molecular layer
absent cerebellum fissure
abnormal cerebellum vermis lobule morphology
cerebellum atrophy
cerebellum hypoplasia
astrocytosis
decreased oligodendrocyte number
Availability Mouse Genotype
Wwoxem1Mald/Wwoxem1Mald
Wwoxtm1.1Mald/Wwoxtm1.1Mald
Wwoxtm1Ria/Wwoxtm1Ria
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory