Symbol Name ID |
Fus
fused in sarcoma MGI:1353633 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Neurodegeneration |
Neuronal loss in central nervous system |
Fasciculations |
Action tremor |
Postural tremor |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Atypical behavior |
Agitation |
Cognitive impairment |
Frontotemporal dementia |
Sleep abnormality |
Hyperreflexia |
Jaw hyperreflexia |
Hyporeflexia |
Gait disturbance |
Disease(s) Associated with FUS | ||||||||||||||||||||||||||||
amyotrophic lateral sclerosis | ||||||||||||||||||||||||||||
amyotrophic lateral sclerosis type 6 | ||||||||||||||||||||||||||||
essential tremor 4 |
Mouse Phenotypes | nervous system phenotype |
abnormal hippocampus pyramidal cell morphology |
decreased motor neuron number |
motor neuron degeneration |
abnormal neuromuscular synapse morphology |
increased prepulse inhibition |
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Availability | Mouse Genotype | ||||||
FusGt(U3NeoSV1)HO14Ggh/FusGt(U3NeoSV1)HO14Ggh | |||||||
Fustm1.1(KOMP)Vlcg/Fus+ | |||||||
Fustm1.1Emcf/Fus+ | |||||||
Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi Chattm2(cre)Lowl/Chat+ (conditional) |
* | ||||||
Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi Ndor1Tg(UBC-cre/ERT2)1Ejb/0 (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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