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Symbol
Name
ID 		Tbp
TATA box binding protein
MGI:101838
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Hyposmia
Orthostatic hypotension due to autonomic dysfunction
Dysphagia
Frequent falls
Gliosis
Substantia nigra gliosis
Cerebral cortical atrophy
Diffuse cerebral atrophy
Lewy bodies
Cerebellar atrophy
Neuronal loss in central nervous system
Ataxia
Dysmetria
Gait ataxia
Limb ataxia
Bradykinesia
Parkinsonism
Parkinsonism with favorable response to dopaminergic medication
Apraxia
Chorea
Myoclonus
Tremor
Intention tremor
Resting tremor
EEG abnormality
Monotonic speech
Dysarthria
Mutism
Depression
Low frustration tolerance
Paranoia
Delusion
Lack of insight
Schizophrenia
Hallucinations
Visual hallucination
Apathy
Negativism
Personality changes
Polydipsia
Polyphagia
Aggressive behavior
Impulsivity
Agitation
Confusion
Mental deterioration
Dementia
Frontal lobe dementia
Social and occupational deterioration
Micrographia
Sleep abnormality
Akinesia
Dyskinesia
Dystonia
Frontal release signs
Broad-based gait
Shuffling gait
Short stepped shuffling gait
Postural instability
Seizure
Positive Romberg sign
Abnormal autonomic nervous system physiology
Disease(s) Associated with TBP
late onset Parkinson's disease
schizophrenia
spinocerebellar ataxia type 17
type 1 diabetes mellitus

Mouse Phenotypes
Purkinje cell degeneration
abnormal Purkinje cell dendrite morphology
thin cerebellar molecular layer
cerebellum hypoplasia
Availability Mouse Genotype
Tbptm1Xjl/Tbptm1Xjl
Tg(Nes-cre)1Kln/?  (conditional)
Tbptm1Xjl/Tbp+
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory