Symbol
Name
ID

Rag2
recombination activating gene 2
MGI:97849

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Reduced antigen-specific T cell proliferation

Decreased lymphocyte proliferation in response to mitogen

Decreased circulating IgA level

Decreased circulating IgG level

Decreased circulating total IgM

Decreased circulating antibody level

Panhypogammaglobulinemia

Autoimmune hemolytic anemia

Eosinophilia

Abnormal B cell count

B lymphocytopenia

Severe B lymphocytopenia

Abnormal T cell count

Decreased proportion of CD3-positive T cells

T lymphocytopenia

Lymphopenia

Abnormal natural killer cell count

Recurrent upper and lower respiratory tract infections

Conjunctivitis

Lymphadenitis

Lymphadenopathy

Hypoplasia of the thymus

Splenomegaly

Hepatosplenomegaly

Otitis media

Erythroderma

Skin rash

Pneumonia

Autoimmunity

Combined immunodeficiency

Severe combined immunodeficiency

Recurrent opportunistic infections

Failure to thrive secondary to recurrent infections

Recurrent bacterial infections

Recurrent fungal infections

Recurrent respiratory infections

Recurrent viral infections

Recurrent enteroviral infections

Meningitis

Disease(s) Associated with RAG2

combined cellular and humoral immune defects with granulomas

Omenn syndrome

severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive

Mouse Phenotypes

decreased T cell proliferation

colitis

abnormal thymus morphology

absent Hassall's corpuscle

thymus hypoplasia

decreased thymocyte number

abnormal B cell differentiation

decreased immature B cell number

absent immature B cells

increased immature B cell number

abnormal immunoglobulin V(D)J recombination

arrested B cell differentiation

abnormal T cell receptor V(D)J recombination

abnormal double-negative T cell morphology

decreased double-negative T cell number

increased double-negative T cell number

abnormal double-positive T cell morphology

decreased double-positive T cell number

abnormal gamma-delta T cell differentiation

arrested T cell differentiation

increased granulocyte number

abnormal B cell number

decreased mature B cell number

absent mature B cells

decreased follicular B cell number

decreased marginal zone B cell number

increased plasma cell number

decreased B cell number

decreased pre-B cell number

absent pre-B cells

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased T cell number

decreased lymphocyte cell number

increased macrophage cell number

decreased monocyte cell number

abnormal B cell morphology

abnormal T cell morphology

abnormal effector T cell morphology

abnormal spleen morphology

small spleen

spleen hypoplasia

decreased spleen white pulp amount

abnormal lymphocyte physiology

abnormal B cell physiology

abnormal B cell activation

decreased IgA level

decreased IgG level

decreased IgM level

increased natural killer cell mediated cytotoxicity

abnormal T-helper 1 physiology

abnormal macrophage physiology

abnormal immune system cell morphology

abnormal immune system organ morphology

abnormal Peyer's patch morphology

absent Peyer's patches

abnormal lymph node morphology

small lymph nodes

lymph node hypoplasia

small cervical lymph nodes

small inguinal lymph nodes

decreased susceptibility to type IV hypersensitivity reaction

abnormal humoral immune response

abnormal chemokine secretion

abnormal interferon secretion

lung inflammation

erythroderma

decreased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to bacterial infection

decreased susceptibility to parasitic infection

increased susceptibility to infection

abnormal response to transplant

Availability

Mouse Genotype

Rag1/Rag2^tm1Mnz/Rag1/Rag2^tm1Mnz

Rag2^m1Btlr/Rag2^m1Btlr

Rag2^tm1.1Cgn/Rag2^tm1.1Cgn

Rag2^tm1.1Desi/Rag2^tm1.1Desi

Rag2^tm1Avla/Rag2^tm1Avla

Rag2^tm1Fwa/Rag2^tm1Fwa

Rag2^tm1Libo/Rag2^tm1Libo

Rag2^tm1Mao/Rag2^tm1Mao

Rag2^tm1Tgi/Rag2^tm1Tgi

Rag2^tm1Fwa/Rag2^tm1Mao

Rag2^tm1Cgn/Rag2^tm1.1Cgn
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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