|
Symbol Name ID |
Irf8
interferon regulatory factor 8 MGI:96395 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Abnormal circulating IgG level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Eosinophilia |
Neutrophilia |
Monocytopenia |
Leukopenia |
Impaired oxidative burst |
Sinusitis |
Pericarditis |
Lymphadenitis |
Lymphadenopathy |
Splenomegaly |
Iridocyclitis |
Epididymitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Granuloma |
Abnormality of immune system physiology |
Erythema nodosum |
Discoid lupus rash |
Malar rash |
Pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Immunodeficiency |
BCGitis |
Recurrent infections |
Recurrent respiratory infections |
| Disease(s) Associated with IRF8 | ||||||||||||||||||||||||||||||||||||||||||
| Behcet's disease | ||||||||||||||||||||||||||||||||||||||||||
| immunodeficiency 32A | ||||||||||||||||||||||||||||||||||||||||||
| immunodeficiency 32B | ||||||||||||||||||||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | immune system phenotype |
hepatosplenomegaly |
enlarged spleen |
increased spleen weight |
spleen hyperplasia |
increased transitional stage B cell number |
abnormal myelopoiesis |
increased neutrophil cell number |
increased granulocyte number |
decreased follicular B cell number |
increased mature B cell number |
increased B-1b cell number |
increased B-2 B cell number |
increased follicular B cell number |
increased marginal zone B cell number |
decreased B cell number |
increased B cell number |
increased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased T cell number |
decreased lymphocyte cell number |
increased lymphocyte cell number |
decreased macrophage cell number |
increased macrophage cell number |
decreased monocyte cell number |
increased leukocyte cell number |
abnormal plasma cell number |
increased spleen red pulp amount |
abnormal spleen marginal zone morphology |
increased immunoglobulin level |
abnormal cytotoxic T cell physiology |
enlarged lymph nodes |
abnormal humoral immune response |
abnormal interferon secretion |
decreased interferon-gamma secretion |
increased susceptibility to Riboviria infection |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||
| Irf8M1Btlr/Irf8M1Btlr | |||||||||||||||||||||||||||||||||||||
| Irf8m2Btlr/Irf8m2Btlr | |||||||||||||||||||||||||||||||||||||
| Irf8myls/Irf8myls | |||||||||||||||||||||||||||||||||||||
| Irf8tm1Hor/Irf8tm1Hor | |||||||||||||||||||||||||||||||||||||
| Irf8myls/Irf8+ | |||||||||||||||||||||||||||||||||||||
| Cd19tm1(cre)Cgn/Cd19+ Irf8tm1.1Hm/Irf8tm1.1Hm (conditional) |
* | ||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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