Symbol
Name
ID

Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
MGI:88192

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Subacute progressive viral hepatitis	Recurrent infections
Disease(s) Associated with SMARCA4	Subacute progressive viral hepatitis	Recurrent infections
Coffin-Siris syndrome 4
hepatocellular carcinoma

Mouse Phenotypes

immune system phenotype

thymus hypoplasia

decreased thymocyte number

abnormal T cell differentiation

decreased double-negative T cell number

decreased double-positive T cell number

arrested T cell differentiation

decreased CD4-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

decreased single-positive T cell number

abnormal T cell morphology

Availability

Mouse Genotype

Smarca4^tm1Tich/Smarca4⁺

Smarca4^tm1.2Pcn/Smarca4^tm1.2Pcn
Tg(Lck-cre)1Cwi/0 (conditional)

Smarca4^tm1.2Pcn/Smarca4^tm1Mag
Tg(Lck-cre)1Cwi/? (conditional)

Smarca4^tm1.2Pcn/Smarca4^tm1Tich
Tg(Lck-cre)1Cwi/0 (conditional)

Smarca4^tm1Tich/Smarca4⁺
Tg(Lck-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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