Symbol
Name
ID

Arpc1b
actin related protein 2/3 complex, subunit 1B
MGI:1343142

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Lymphocytosis

Blepharitis

Lymphadenopathy

Cervical lymphadenopathy

Inflammation of the large intestine

Colonic eosinophilia

Skin rash

Recurrent pneumonia

Perinuclear antineutrophil antibody positivity

Antinuclear antibody positivity

Recurrent infections

Meningitis

Cellulitis

Disease(s) Associated with ARPC1B

immunodeficiency 71

Mouse Phenotypes

decreased transitional stage T2 B cell number

increased CD103-positive CD11b-low dendritic cell number

decreased marginal zone precursor B cell number

increased plasma cell number

decreased KLRG1-positive NK cell number

increased immature NK cell number

decreased Ly6C-positive mature NK cell number

decreased mature NK cell number

increased memory-marker NK cell number

decreased NK cell number

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, alpha-beta memory T cell number

increased KLRG1+ CD4 alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased memory-marker CD4-negative NK T cell number

increased KLRG1-positive T-helper cell number

increased effector memory T-helper cell number

decreased macrophage cell number

increased leukocyte cell number

Availability

Mouse Genotype

Arpc1b^{tm1a(EUCOMM)Wtsi}/Arpc1b^{tm1a(EUCOMM)Wtsi}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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