Symbol
Name
ID

Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
MGI:1314891

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM	Splenomegaly	Recurrent pneumonia
Disease(s) Associated with TNFRSF11A
autosomal recessive osteopetrosis 7

Mouse Phenotypes

abnormal osteoclast differentiation

abnormal Peyer's patch epithelium morphology

abnormal thymus epithelium morphology

enlarged spleen

spleen hyperplasia

abnormal negative T cell selection

increased neutrophil cell number

increased granulocyte number

decreased mature B cell number

decreased plasma cell number

decreased B cell number

decreased osteoclast cell number

increased osteoclast cell number

abnormal osteoclast morphology

decreased spleen germinal center size

decreased IgA level

abnormal osteoclast physiology

abnormal Peyer's patch morphology

abnormal Peyer's patch follicle morphology

abnormal Peyer's patch T cell area morphology

abnormal Peyer's patch germinal center morphology

decreased Peyer's patch number

small Peyer's patches

abnormal mesenteric lymph node morphology

absent lymph nodes

decreased susceptibility to endotoxin shock

Availability

Mouse Genotype

Tnfrsf11a^del8/Tnfrsf11a^del8

Tnfrsf11a^tm1.1Sral/Tnfrsf11a^tm1.1Sral

Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr

Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx

Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost

Tnfrsf11a^tm1.1Sral/Tnfrsf11a⁺

Tg(Vil1-cre)997Gum/0
Tnfrsf11a^tm1.1Irw/Tnfrsf11a^tm1.1Irw (conditional)

Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr
Tg(Nes-cre)1Kln/0 (conditional)

Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr
Tg(Gfap-cre)2Brn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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