Symbol
Name
ID

Lepr
leptin receptor
MGI:104993

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Subacute progressive viral hepatitis
Disease(s) Associated with LEPR	Subacute progressive viral hepatitis
hepatocellular carcinoma

Mouse Phenotypes

white adipose tissue inflammation

abnormal osteoclast differentiation

decreased T cell proliferation

pancreas inflammation

periinsulitis

increased eosinophil cell number

increased neutrophil cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased lymphocyte cell number

increased monocyte cell number

decreased leukocyte cell number

abnormal leukocyte morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

decreased spleen weight

decreased splenocyte number

increased IgE level

increased circulating interleukin-6 level

abnormal chemokine level

abnormal interleukin level

abnormal chemokine secretion

increased interleukin-6 secretion

increased susceptibility to autoimmune diabetes

abnormal acute inflammation

increased susceptibility to endotoxin shock

liver inflammation

kidney inflammation

lung inflammation

increased susceptibility to parasitic infection

decreased response to antigen

Availability

Mouse Genotype

Lepr^db-5J/Lepr^db-5J

Lepr^db-lb/Lepr^db-lb

Lepr^db/Lepr^db

Lepr^m7Btlr/Lepr^m7Btlr

Lepr^m8Btlr/Lepr^m8Btlr

Lepr^tm1.1Rll/Lepr^tm1.1Rll

Lepr^{tm1b(EUCOMM)Wtsi}/Lepr^{tm1b(EUCOMM)Wtsi}

Lepr^tm4Mgmj/Lepr^tm4Mgmj

Lepr^tm1.1Rll/Lepr⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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