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Symbol Name ID |
Rorc
RAR-related orphan receptor gamma MGI:104856 |
| Darker colors indicate more annotations |
| Human Phenotypes | Recurrent aphthous stomatitis |
Hypoplasia of the thymus |
Splenomegaly |
Recurrent cutaneous fungal infections |
Chronic oral candidiasis |
BCGosis |
| Disease(s) Associated with RORC | ||||||
| immunodeficiency 42 |
| Mouse Phenotypes | increased thymocyte apoptosis |
increased T cell apoptosis |
colitis |
salivary gland inflammation |
decreased thymus weight |
thymus hypoplasia |
decreased thymocyte number |
lacrimal gland inflammation |
enlarged spleen |
abnormal T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
abnormal T-helper 17 cell differentiation |
decreased double-negative T cell number |
increased double-negative T cell number |
decreased double-positive T cell number |
decreased B-2 B cell number |
increased B-1a cell number |
increased B-1b cell number |
decreased NK cell number |
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased T cell number |
abnormal T cell morphology |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal CD4-positive, alpha-beta intraepithelial T cell morphology |
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology |
abnormal splenic cell ratio |
decreased IgG2c level |
decreased IgG3 level |
decreased IgG level |
decreased IgM level |
abnormal T cell physiology |
abnormal T-helper 17 cell physiology |
abnormal interleukin level |
abnormal lymph organ development |
abnormal gut-associated lymphoid tissue morphology |
absent Peyer's patches |
small inguinal lymph nodes |
absent lymph nodes |
impaired humoral immune response |
decreased interferon-gamma secretion |
increased interferon-gamma secretion |
decreased interleukin-10 secretion |
increased interleukin-17 secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
increased susceptibility to autoimmune disorder |
increased autoantibody level |
increased anti-nuclear antigen antibody level |
lung inflammation |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
abnormal susceptibility to Picornaviridae infection |
decreased response to antigen |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rorcm1Btlr/Rorcm1Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rorcm2Btlr/Rorcm2Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rorcm3Btlr/Rorcm3Btlr | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rorctm1.1Zsun/Rorctm1.1Zsun | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rorctm1Amj/Rorctm1Amj | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rorctm1Litt/Rorctm1Litt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rorctm2Litt/Rorctm2Litt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(CD2-Rorc)#Staka/0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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