Symbol
Name
ID

Lck
lymphocyte protein tyrosine kinase
MGI:96756

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA level	Decreased circulating IgE	Decreased circulating IgG level	Decreased circulating total IgM	Anemia	Decreased proportion of CD4-positive helper T cells	Thrombocytopenia
Disease(s) Associated with LCK
immunodeficiency 22

Mouse Phenotypes

decreased T cell proliferation

abnormal thymus morphology

thymus atrophy

thymus hypoplasia

decreased thymocyte number

abnormal thymocyte activation

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal double-negative T cell morphology

decreased double-positive T cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased gamma-delta T cell number

decreased gamma-delta intraepithelial T cell number

abnormal intraepithelial T cell number

decreased regulatory T cell number

increased regulatory T cell number

decreased T cell number

decreased single-positive T cell number

increased T cell number

increased activated T cell number

increased single-positive T cell number

abnormal lymphocyte morphology

abnormal T cell morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal alpha-beta intraepithelial T cell morphology

abnormal single-positive T cell number

abnormal intraepithelial T cell morphology

abnormal immunoglobulin level

decreased IgG1 level

increased IgG2a level

increased IgG3 level

decreased IgG level

increased IgM level

decreased cytotoxic T cell cytolysis

abnormal regulatory T cell physiology

Availability

Mouse Genotype

Lck^m1Btlr/Lck^m1Btlr

Lck^m2Btlr/Lck^m2Btlr

Lck^m3Btlr/Lck^m3Btlr

Lck^tm1.1Litt/Lck^tm1.1Litt

Lck^tm1Dbs/Lck^tm1Dbs

Lck^tm1Mak/Lck^tm1Mak

Lck^tm1Litt/Lck^tm1.1Litt
Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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