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Symbol
Name
ID 		Irf8
interferon regulatory factor 8
MGI:96395
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Abnormal circulating IgG level
Increased circulating IgG level
Decreased circulating antibody level
Paraproteinemia
Granulocytic hyperplasia
Anemia
Hemolytic anemia
Eosinophilia
Neutrophilia
Monocytopenia
Leukopenia
Impaired oxidative burst
Superficial thrombophlebitis
Thrombocytopenia
Multiple myeloma
Splenomegaly
Disease(s) Associated with IRF8
Behcet's disease
immunodeficiency 32B
multiple myeloma
systemic lupus erythematosus

Mouse Phenotypes
hepatosplenomegaly
enlarged spleen
increased spleen weight
spleen hyperplasia
abnormal definitive hematopoiesis
abnormal erythropoiesis
increased transitional stage B cell number
abnormal myelopoiesis
increased bone marrow cell number
abnormal megakaryocyte morphology
decreased erythrocyte cell number
increased mean corpuscular hemoglobin
increased mean corpuscular volume
increased neutrophil cell number
increased granulocyte number
thrombocytopenia
decreased follicular B cell number
increased mature B cell number
increased B-1b cell number
increased B-2 B cell number
increased follicular B cell number
increased marginal zone B cell number
decreased B cell number
increased B cell number
increased CD4-positive, alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased T cell number
decreased lymphocyte cell number
increased lymphocyte cell number
decreased macrophage cell number
increased macrophage cell number
decreased monocyte cell number
increased leukocyte cell number
abnormal plasma cell number
increased spleen red pulp amount
abnormal spleen marginal zone morphology
increased immunoglobulin level
abnormal cytotoxic T cell physiology
Availability Mouse Genotype
Irf8M1Btlr/Irf8M1Btlr
Irf8m2Btlr/Irf8m2Btlr
Irf8myls/Irf8myls
Irf8tm1b(KOMP)Wtsi/Irf8tm1b(KOMP)Wtsi
Irf8tm1Hor/Irf8tm1Hor
Irf8myls/Irf8+
Irf8tm1Hor/Irf8+
Cd19tm1(cre)Cgn/Cd19+
Irf8tm1.1Hm/Irf8tm1.1Hm  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory