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Symbol
Name
ID 		Ikbkg
inhibitor of kappaB kinase gamma
MGI:1338074
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Reduced natural killer cell activity
Increased circulating IgA level
Abnormal circulating IgG level
Decreased circulating total IgM
Increased circulating IgM level
Dysgammaglobulinemia
Retinal hemorrhage
Eosinophilia
Leukocytosis
Superficial thrombophlebitis
Disease(s) Associated with IKBKG
Behcet's disease
Bloch-Sulzberger syndrome
ectodermal dysplasia and immunodeficiency 1
immunodeficiency 33

Mouse Phenotypes
increased T cell apoptosis
increased B cell proliferation
small thymus
enlarged spleen
abnormal B cell differentiation
decreased immature B cell number
abnormal bone marrow cell morphology/development
absent megakaryocytes
decreased mature B cell number
decreased B-1 B cell number
decreased follicular B cell number
decreased marginal zone B cell number
decreased B cell number
decreased NK cell number
decreased CD4-positive, alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased NK T cell number
decreased regulatory T cell number
decreased T cell number
decreased single-positive T cell number
small spleen
abnormal NK cell physiology
abnormal NK T cell physiology
Availability Mouse Genotype
Ikbkgtm1.1Dwat/Ikbkg+
Ikbkgtm1Mka/Ikbkg+
Ikbkgm1Btlr/Y
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
Tg(Alb1-cre)7Gsc/0  (conditional)
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Cd79atm1(cre)Reth/Cd79a+  (conditional)
Cd19tm1(cre)Cgn/Cd19+
Ikbkgtm1.1Mpa/Y  (conditional)
Ikbkgtm1.1Chtr/Y
Tg(Alb1-cre)7Gsc/0  (conditional)
Ikbkgtm1.1Mpa/Y
Tg(Cd4-cre)1Cwi/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory