Symbol Name ID |
Itch
itchy, E3 ubiquitin protein ligase MGI:1202301 |
Darker colors indicate more annotations |
Mouse Phenotypes | increased regulatory T cell apoptosis |
enlarged spleen |
increased spleen weight |
abnormal lymphopoiesis |
abnormal T-helper 2 cell differentiation |
increased eosinophil cell number |
increased mean corpuscular volume |
decreased CD4-positive, alpha-beta T cell number |
increased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
increased regulatory T cell number |
increased leukocyte cell number |
abnormal immunoglobulin level |
increased IgA level |
increased IgE level |
increased IgG1 level |
abnormal T-helper 2 physiology |
abnormal regulatory T cell physiology |
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Availability | Mouse Genotype | ||||||||||||||||||
Itchtm1b(EUCOMM)Hmgu/Itchtm1b(EUCOMM)Hmgu | |||||||||||||||||||
Itchtm1(NCOM)Cmhd/Itch+ | |||||||||||||||||||
Itchtm1.1Alta/Itchtm1.1Alta Foxp3tm4(YFP/icre)Ayr/Foxp3+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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