Symbol
Name
ID

Chd7
chromodomain helicase DNA binding protein 7
MGI:2444748

Phenotype annotations related to cellular

Darker colors indicate more annotations

Mouse Phenotypes

decreased fetal cardiomyocyte proliferation

increased cardiomyocyte apoptosis

abnormal olfactory epithelium cilium morphology

increased middle ear goblet cell number

decreased oligodendrocyte progenitor number

increased cellular sensitivity to oxidative stress

abnormal oligodendrocyte apoptosis

increased neuron apoptosis

increased granulosa cell apoptosis

decreased apoptosis

abnormal neuron differentiation

premature neuronal precursor differentiation

abnormal neural crest cell migration

decreased cerebellar granule cell precursor proliferation

abnormal neuronal precursor proliferation

decreased cell proliferation

abnormal epigenetic regulation of gene expression

Availability

Mouse Genotype

Chd7^{Gt(S20-7E1)Sor}/Chd7^{Gt(S20-7E1)Sor}

Chd7^{tm2a(EUCOMM)Wtsi}/Chd7^{tm2a(EUCOMM)Wtsi}

Chd7^{Gt(S20-7E1)Sor}/Chd7⁺

Chd7^Gt(XK403)Byg/Chd7⁺

Chd7^Ome/Chd7⁺

Chd7^tm1.1Dmm/Chd7^tm1.1Dmm
Tg(Pdgfra-cre/ERT)467Dbe/0 (conditional)

Chd7^{tm2c(EUCOMM)Wtsi}/Chd7^{tm2c(EUCOMM)Wtsi}
Tg(Gdf9-icre)5092Coo/0 (conditional)

Chd7^{tm2c(EUCOMM)Wtsi}/Chd7^{tm2c(EUCOMM)Wtsi}
Tg(Atoh1-cre)1Bfri/0 (conditional)

Chd7^{tm2c(EUCOMM)Wtsi}/Chd7^{tm2c(EUCOMM)Wtsi}
Slc1a3^{tm1(cre/ERT2)Mgoe}/Slc1a3⁺ (conditional)

Chd7^{Gt(S20-7E1)Sor}/Chd7^tm1.1Dmm
Foxg1^tm1(cre)Skm/Foxg1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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