Symbol
Name
ID

Ikbkg
inhibitor of kappaB kinase gamma
MGI:1338074

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Reduced natural killer cell activity	Increased circulating IgA level	Abnormal circulating IgG level	Decreased circulating total IgM	Increased circulating IgM level	Dysgammaglobulinemia
Disease(s) Associated with IKBKG	Reduced natural killer cell activity	Increased circulating IgA level	Abnormal circulating IgG level	Decreased circulating total IgM	Increased circulating IgM level	Dysgammaglobulinemia
ectodermal dysplasia and immunodeficiency 1
immunodeficiency 33

Mouse Phenotypes

azoospermia

abnormal hepatocyte mitochondrial morphology

increased T cell apoptosis

increased fibroblast apoptosis

increased keratinocyte apoptosis

increased apoptosis

increased hepatocyte apoptosis

hepatic necrosis

increased B cell proliferation

increased cell proliferation

increased hepatocyte proliferation

Availability

Mouse Genotype

Ikbkg^tm1Mka/Ikbkg⁺

Ikbkg^tm1Mpa/Ikbkg⁺

Ikbkg^m1Btlr/Y

Ikbkg^tm1Mak/Y

Ikbkg^tm1Mka/Y

Ikbkg^tm1Mpa/Y

Ikbkg^tm1.1Chtr/Ikbkg^tm1.1Chtr
Tg(Alb1-cre)7Gsc/0 (conditional)

Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa
Tg(Alb1-cre)7Gsc/0 (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Ikbkg^tm1.1Mpa/Y (conditional)

Ikbkg^tm1.1Chtr/Y
Tg(Alb1-cre)7Gsc/0 (conditional)

Ikbkg^tm1.1Mpa/Y
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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