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All mouse models of renal tubular transport disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | autosomal dominant pseudohypoaldosteronism type 1 | Nr3c2tm1Gsc/Nr3c2tm1Gsc | involves: 129P2/OlaHsd * C57BL/6 | J:77285 | View | |||
| Bartter disease type 1 | Slc12a1tm1Tkh/Slc12a1tm1Tkh | involves: 129S6/SvEvTac | J:62224 | View | ||||
| Bartter disease type 1 | Slc12a1urehr3/Slc12a1urehr3 | involves: C3HeB/FeJ | J:159994 | View | ||||
| Bartter disease type 2 | Kcnj1tm1Ges/Kcnj1tm1Ges | involves: 129X1/SvJ * Black Swiss | J:79354 | View | ||||
| Bartter disease type 3 | Clcnkbem1Haca/Clcnkbem1Haca | C57BL/6-Clcnkbem1Haca | J:259681 | View | ||||
| Bartter disease type 4a | Bsndtm1.1Suc/Bsndtm1.1Suc | involves: 129S4/SvJae * C57BL/6 | J:175265 | View | ||||
| Bartter disease type 4a |
Bsndtm1Tjj/Bsndtm1Tjj Tg(Sox10-cre)1Wdr/0 |
involves: 129/Sv * 129X1/SvJ * C57BL/6 | J:143314 | View | ||||
| Dent disease | Clcn5tm1Gug/Y | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:66560 | View | ||||
| Dent disease | Clcn5tm1Tjj/Y | B6.129-Clcn5tm1Tjj | J:77111 | View | ||||
| Gitelman syndrome | Slc12a3em3Gpt/Slc12a3em4Gpt | involves: C57BL/6 | J:336073 | View | ||||
| Gitelman syndrome | Slc12a3tm1Ges/Slc12a3tm1Ges | Not Specified | J:50596 | View | ||||
| Liddle syndrome | Scnn1btm1.1Ipt/Scnn1btm1.1Ipt | involves: 129P2/OlaHsd * C57BL/6J * FVB/N | J:59840 | View | ||||
| pseudohypoaldosteronism | Klhl3tm1.1Esoh/Klhl3+ | involves: C57BL/6 | J:214330 | View | ||||
| pseudohypoaldosteronism | Klhl3tm1.1Slin/Klhl3+ | Not Specified | J:284284 | View | ||||
| pseudohypoaldosteronism | Klhl3tm1.1Slin/Klhl3tm1.1Slin | Not Specified | J:284284 | View | ||||
| pseudohypoaldosteronism | Klhl3tm2.1Esoh/Klhl3tm2.1Esoh | involves: C57BL/6 * C57BL/6J | J:244278 | View | ||||
| pseudohypoaldosteronism | Wnk4em1Cjc/Wnk4em1Cjc | Not Specified | J:274218 | View | ||||
| renal tubular acidosis | Atp6v0a4tm1.1Fekf/Atp6v0a4tm1.1Fekf | involves: C57BL/6 | J:188593 | View | ||||
| renal tubular acidosis | Slc4a1tm1Llp/Slc4a1tm1Llp | involves: 129S4/SvJae * C57BL/6J | J:148154 | View | ||||
| renal tubular acidosis | Slc4a4tm1.1Slin/Slc4a4tm1.1Slin | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:186877 | View | ||||
| | autosomal recessive pseudohypoaldosteronism type 1 | Scnn1btm1Wsh/Scnn1btm1Wsh | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:53058 | View | |||
| autosomal recessive pseudohypoaldosteronism type 1 | Scnn1gtm1Bhk/Scnn1gtm1Bhk | involves: 129P2/OlaHsd * C57BL/6 * DBA/2 | J:50528 | View | ||||
| Bartter disease | Clcnkbtm1.1Doel/Clcnkbtm1.1Doel | involves: 129S1/Sv * 129X1/SvJ | J:259639 | View | ||||
| Fanconi syndrome |
Hnf4atm1Sad/Hnf4atm1Sad Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ |
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J | J:266356 | View | ||||
| Fanconi syndrome | Lrp2tm1Her/Lrp2tm1Her | involves: 129S7/SvEvBrd | J:108230 | View | ||||
| Gitelman syndrome | Stk39tm1.2Slin/Stk39tm1.2Slin | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:165706 | View | ||||
| Gitelman syndrome | Stk39tm1Pawe/Stk39tm1Pawe | involves: 129S6/SvEvTac * C57BL/6J | J:287773 | View | ||||
| Gitelman syndrome | Stk39tm2.1Arte/Stk39tm2.1Arte | involves: C57BL/6J | J:224087 | View | ||||
| Gitelman syndrome | Wnk4tm1Pfi/Wnk4tm1Pfi | involves: 129S6/SvEvTac * C57BL/6J | J:184790 | View | ||||
| pseudohypoaldosteronism |
Stk39tm1Pawe/Stk39tm1Pawe Pvalbtm1(cre)Arbr/Pvalb+ |
B6.129-Stk39tm1Pawe Pvalbtm1(cre)Arbr | J:287773 | View | ||||
| renal glycosuria |
Hnrnpftm1Jsdc/Hnrnpftm1Jsdc Pax8tm1.1(cre)Mbu/Pax8+ |
involves: 129P2/OlaHsd * C57BL/6 | J:284239 | View | ||||
| | Dent disease |
Inpp5btm1Nbm/Inpp5btm1Nbm Ocrltm1Nbm/Ocrltm1Nbm Tg(INPP5B)CNbm/0 |
involves: 129S/SvEv * 129S6/SvEvTac * FVB/N | J:185879 | View | |||
| Dent disease |
Inpp5btm1Nbm/Inpp5btm1Nbm Ocrltm1Nbm/Y Tg(INPP5B)CNbm/0 |
involves: 129S/SvEv * 129S6/SvEvTac * FVB/N | J:185879 | View | ||||
| Additional Complex Models | autosomal recessive pseudohypoaldosteronism type 1 |
Scnn1atm1Rss/Scnn1atm1Rss Tg(CMV-Scnn1a)1352Rss/0 |
involves: 129P2/OlaHsd * NMRI | J:43583 | View | |||
| renal tubular transport disease | Igktm1.1Cog/Igktm1.1Cog | involves: 129P2/OlaHsd * C57BL/6 * FVB/N | J:135758 | View | ||||
| renal tubular transport disease | Igktm1.1Cog/Igktm1.2Cog | involves: 129P2/OlaHsd * C57BL/6 * FVB/N | J:135758 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | pseudohypoaldosteronism | Cul3tm1Suc/Cul3+ | involves: C57BL/6 | J:226618 | View | |||
| pseudohypoaldosteronism | Cul3tm2Suc/Cul3tm2Suc | involves: C57BL/6 | J:226618 | View | ||||