About   Help   FAQ
Bsndtm1.1Suc
Targeted Allele Detail
Summary
Symbol: Bsndtm1.1Suc
Name: barttin CLCNK type accessory beta subunit; targeted mutation 1.1, Shinichi Uchida
MGI ID: MGI:5285211
Synonyms: BsndR8L
Gene: Bsnd  Location: Chr4:106340653-106349440 bp, - strand  Genetic Position: Chr4, 49.67 cM
Alliance: Bsndtm1.1Suc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175265
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Humanized sequence, Modified isoform(s))
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsCre-mediated recombination removed the neo cassette downstream of the modified exon 1 with the R8L substitution (mimicking a mutation found in some Bartter syndrome patients) and removed by cre-mediated recombination. (J:175265)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bsnd Mutation:  16 strains or lines available
References
Original:  J:175265 Nomura N, et al., Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol. 2011 Aug;301(2):F297-307
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
06/12/2024
MGI 6.13
The Jackson Laboratory