About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3826852
Allelic
Composition
Bsndtm1Tjj/Bsndtm1Tjj
Tg(Sox10-cre)1Wdr/0
Genetic
Background
involves: 129/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bsndtm1Tjj mutation (0 available); any Bsnd mutation (16 available)
Tg(Sox10-cre)1Wdr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• mice exhibit abnormal gain and phase of angular vestibulo ocular reflexes (VOR) in the dark compared to wild-type mice
• however, VORs in the light are normal
• after 3 weeks, outer hair cells in the basal turn begin to degenerate
• as the stria vascularis degenerates it loses the normal interdigitation of marginal and intermediate cells
• however, all cell types are retained
• at 2 weeks, the width of the stria vascularis is reduced by 30% to 50% compared to in wild-type mice
• between P20 and P30
• at 3 weeks, mice exhibit hearing loss of about 60 dB as measured by auditory brainstem response that is less severe than in Slc12a2tm2Bhk homozygotes

behavior/neurological
• mice exhibit abnormal gain and phase of angular vestibulo ocular reflexes (VOR) in the dark compared to wild-type mice
• however, VORs in the light are normal

nervous system
• after 3 weeks, outer hair cells in the basal turn begin to degenerate

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Bartter disease type 4a DOID:0110145 OMIM:602522
J:143314


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/28/2024
MGI 6.13
The Jackson Laboratory