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All mouse models of squamous cell carcinoma with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
 | skin squamous cell carcinoma | Tg(KRT14-Fyn*)aJsey/0 | involves: C57BL/6 * CBA * FVB/N | J:155536 | View | |||
 | squamous cell carcinoma |
Dicer1tm1Snj/Dicer1tm1Snj Trp53tm1Brn/Trp53tm1Brn Tg(KRT5-cre/PGR)1Der/0 |
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6N * FVB/N * ICR | J:216813 | View | |||
| squamous cell carcinoma |
Krastm4Tyj/Kras+ Trp53tm1Brn/Trp53tm1Brn Tg(KRT14-cre/ERT)20Efu/0 |
involves: 129P2/OlaHsd * 129S4/SvJae * CD-1 | J:172048 | View | ||||
| Transgenes and Other Mutations | adenosquamous lung carcinoma |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-ERBB2*)5BKkw/0 |
involves: FVB/N | J:143874 | View | |||
| adenosquamous lung carcinoma |
Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-ERBB2*)26Kkw/0 |
involves: FVB/N | J:143874 | View | ||||
| skin squamous cell carcinoma | Tg(KRT14-HPV16)wt1Dh/0 | either: FVB.Cg-Tg(KRT14-HPV16)wt1Dh or (involves: C57BL/6 * DBA/2 * FVB/N) | J:20130 | View | ||||
| Additional Complex Models | head and neck squamous cell carcinoma |
Ptentm1Hwu/Ptentm1Hwu Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl Tg(KRT14-cre/ERT)20Efu/0 |
involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N | J:194652 | View | |||
| head and neck squamous cell carcinoma |
Tg(KRT14-cre)8Brn/0 Tg(KRT5-Akt1*)Jmpa/0 Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N | J:144831 | View | ||||
| lung squamous cell carcinoma |
Nr1h2tm1.1Gstr/Nr1h2tm1.1Gstr Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:234268 | View | ||||
| squamous cell carcinoma |
Krastm4Tyj/Kras+ Smad4tm2.1Cxd/Smad4tm2.1Cxd Tg(Krt1-15-cre/PGR*)22Cot/0 |
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL/J | J:203922 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | skin squamous cell carcinoma | Tg(KRT14-HPV16)wt1Dh/0 | C.Cg-Tg(KRT14-HPV16)wt1Dh | J:20130 | View | |||
| skin squamous cell carcinoma | Tg(KRT14-HPV16)wt1Dh/0 | either: (involves: C57BL/6 * DBA/2) or (involves: C57BL/6 * DBA/2 * SENCAR * SSIN) | J:20130 | View | ||||